UVRAG Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-18885

Novus Biologicals, part of Bio-Techne
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NBP1-18885
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Key Product Details

Validated by

Independent Antibodies, Biological Validation

Species Reactivity

Validated:

Human

Cited:

Human

Applications

Validated:

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Immunoprecipitation, Knockout Validated, Western Blot

Cited:

Immunocytochemistry/ Immunofluorescence, Immunoprecipitation, Knockout Validated, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

0.2 mg/ml

View all UVRAG Antibodies »

Product Specifications

Immunogen

The immunogen recognized by this antibody maps to a region between residue 649 and 699 of human UV radiation resistance associated gene using the numbering given in entry NP_003360.2 (GeneID 7405).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for UVRAG Antibody

Western Blot: UVRAG Antibody [NBP1-18885]

Western Blot: UVRAG Antibody [NBP1-18885]

Western Blot: UVRAG Antibody [NBP1-18885] - Beclin 1 is acetylated at lysines 430 and 437. TSA and NAM increase the binding of Beclin 1 to Rubicon. Immunoprecipitation of indicated Beclin 1-binding partners with ectopically expressed Flag-Beclin 1 in HEK293T cells treated with TSA and NAM. Image collected and cropped by CiteAb from the following publication (https://www.nature.com/articles/ncomms8215), licensed under a CC-BY license.
Immunohistochemistry-Paraffin: UVRAG Antibody [NBP1-18885]

Immunohistochemistry-Paraffin: UVRAG Antibody [NBP1-18885]

Immunohistochemistry-Paraffin: UVRAG Antibody [NBP1-18885] - Section of human colon carcinoma. Antibody: Affinity purified rabbit anti- UVRAG used at a dilution of 1:200 (1ug/ml). Detection: DAB
Western Blot: UVRAG Antibody [NBP1-18885]

Western Blot: UVRAG Antibody [NBP1-18885]

Western Blot: UVRAG Antibody [NBP1-18885] - Whole cell lysate from HeLa and 293T cells. UVRAG was also immunoprecipitated by rabbit anti-UVRAG antibody NBP1-18884.
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Applications for UVRAG Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

Reported in scientific literature (PMID: 30488027)

Immunohistochemistry

1:100-1:500

Immunohistochemistry-Paraffin

1:100-1:500

Immunoprecipitation

2 - 5 ug/mg lysate

Western Blot

1:2000-1:10000
Application Notes
Epitope retrieval with citrate buffer pH6.0 is recommended for FFPE tissue sections.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

TBS and 0.1% BSA

Preservative

0.09% Sodium Azide

Concentration

0.2 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C. Do not freeze.

Background: UVRAG

This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer.

Long Name

UV Radiation Resistance Associated

Alternate Names

DHTX, VPS38

Entrez Gene IDs

7405 (Human)

Gene Symbol

UVRAG

UniProt

NP_003360.2 (Human)

Additional UVRAG Products

Product Documents for UVRAG Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for UVRAG Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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