VABP Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-19020

Novus Biologicals, part of Bio-Techne
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NBP2-19020
NBP2-19020SS
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Key Product Details

Species Reactivity

Human, Mouse, Rat, Porcine, Bovine

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

0.5 mg/ml

View all VABP Antibodies »

Product Specifications

Immunogen

Within the range of amino acids 1-35 (LQTKQRRPSKDKIEDELE) of human ABP protein were used as the immunogen (NP_055407).

Specificity

The Uniprot number for VABP is Q9NZI2.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for VABP Antibody

Western Blot: VABP Antibody [NBP2-19020]

Western Blot: VABP Antibody [NBP2-19020]

Western Blot: VABP Antibody [NBP2-19020] - Analysis of VABP in (A) human brain and (B) human heart cell lysateusing this antibody at 1 ug/ml.

Applications for VABP Antibody

Application
Recommended Usage

Western Blot

1:100-1:2000

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS containing 0.2% gelatin

Preservative

0.05% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: VABP

The gene encodes an EF hand-containing small calcium binding protein. It is an integral subunit component of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Kv4 potassium channels regulate action potentials in neurons and cardiac myocytes. The coexpression of ABP with pore-forming Kv4 alpha subunits causes changes in the gating and amplitude of Kv4 currents, thus profoundly affect the intracellular trafficking and molecular properties of Kv4.2 alpha subunits. It also cause a dramatic redistribution of Kv4.2, releasing intrinsic endoplasmic reticulum retention and allowing for trafficking to the cell surface. It may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. It maps to 5q35.1 region of human chromosome. Alternative splicing results in multiple transcript variant encoding different isoforms. Isoform 1 and isoform 2 are expressed in brain and kidney.

Alternate Names

A-type potassium channel modulatory protein 1, KChIP1, KCHIP1MGC95, Kv channel interacting protein 1, Kv channel-interacting protein 1, potassium channel interacting protein 1, Potassium channel-interacting protein 1, VABP, Vesicle APC-binding protein

Entrez Gene IDs

30820 (Human)

Gene Symbol

KCNIP1

UniProt

Q9NZI2 (Human)

Additional VABP Products

Product Documents for VABP Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for VABP Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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