VHLL Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-84330

Novus Biologicals, part of Bio-Techne
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NBP2-84330-0.1ml
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Key Product Details

Species Reactivity

Validated:

Human

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit

Concentration

0.5 mg/ml

View all VHLL Antibodies »

Product Summary for VHLL Antibody

Immunogen

The immunogen is a synthetic peptide directed towards the N-terminal region of Human VHLL. Peptide sequence: PWRAGNGVGLEAQAGTQEAGPEEYCQEELGAEEEMAARAAWPVLRSVNSR The peptide sequence for this immunogen was taken from within the described region.

Clonality

Polyclonal

Host

Rabbit

Scientific Data Images for VHLL Antibody

Western Blot: VHLL Antibody [NBP2-84330]

Western Blot: VHLL Antibody [NBP2-84330]

Western Blot: VHLL Antibody [NBP2-84330] - Host: Rabbit. Target Name: VHLL. Sample Type: Hela Whole Cell lysates. Antibody Dilution: 1.0ug/ml

Applications for VHLL Antibody

Application
Recommended Usage

Western Blot

1.0 ug/ml
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, 2% Sucrose

Preservative

0.09% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: VHLL

Von Hippel-Lindau (VHL) tumor suppressor protein is a component of an E3 ubiquitin ligase complex that the selectivelyubiquitinates the alpha subunit of the hypoxia-inducible factor (HIF) transcription factor for proteasome-mediateddegradation. Inactivation of VHL causes VHL disease and sporadic kidney cancer. This gene encodes a VHL homolog thatlacks one of two key domains necessary for VHL function. It binds HIF alpha but fails to recruit the E3 ubiquitinligase complex, and therefore functions as a dominant-negative VHL and a protector of HIF alpha. This gene isintronless and predominantly expressed in the placenta, and may contribute to the regulation of oxygen homeostasis andneovascularization during placenta development. (provided by RefSeq)

Alternate Names

VHL-like protein, VHLP, VLPVHL pseudogene, von Hippel-Lindau tumor suppressor-like, von Hippel-Lindau-like protein

Gene Symbol

VHLL

Additional VHLL Products

Product Documents for VHLL Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for VHLL Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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