WASF1/WAVE1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-83018

Novus Biologicals, part of Bio-Techne
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NBP1-83018
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Mouse (97%), Rat (94%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all WASF1/WAVE1 Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: PRAPHDRRREWQKLAQGPELAEDDANLLHKHIEVANGPASHFETRPQTYVDHMDGSYSLSALPFSQMSELLTRAEERVLVRPHEPPPPPPMHGAGDAKPIPTCISSATGLIENRPQSPATGRTPVFVSPTP

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for WASF1/WAVE1 Antibody

Western Blot: WASF1/WAVE1 Antibody [NBP1-83018]

Western Blot: WASF1/WAVE1 Antibody [NBP1-83018]

Western Blot: WASF1/WAVE1 Antibody [NBP1-83018] - Lane 1: Marker [kDa] 250, 130, 100, 70, 55, 35, 25, 15, 10. Lane 2: HEL
Immunohistochemistry: WASF1/WAVE1 Antibody [NBP1-83018]

Immunohistochemistry: WASF1/WAVE1 Antibody [NBP1-83018]

Immunohistochemistry: WASF1/WAVE1 Antibody [NBP1-83018] - Staining of human cerebral cortex shows strong cytoplasmic positivity in neuronal cells.

Applications for WASF1/WAVE1 Antibody

Application
Recommended Usage

Immunohistochemistry

1:20 - 1:50

Immunohistochemistry-Paraffin

1:20 - 1:50

Western Blot

0.04-0.4 ug/ml
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: WASF1/WAVE1

WASP (for Wiskott-Aldrich syndrome protein), N-WASP are downstream effectors of Cdc42 that are implicated in actin polymerization and cytoskeletal organization. The WASP family also includes VASP (vasodilator-stimulated phosphoprotein) and Mena (for mammalian enabled protein), which accumulate at focal adhesions and are also involved in the regulation of the actin cytoskeleton. The WAVE proteins are related to the WASP family proteins and are likewise involved in mediating actin reorganization downstream of the Rho family of small GTPases. The two protein homologs WAVE1 and WAVE2 specifically regulate membrane ruffling by inducing the formation of actin filament clusters in response to GTP binding and activating Rac. The WAVE proteins mediate this actin polymerization by cooperating with the Arp2/3 complex, a nucleation core, and thereby promoting the formation of actin filaments. WAVE1, which is also designated SCAR (for suppressor of cAR), is expressed primarily in the brain, while WAVE2 is widely expressed with the expression highest in peripheral blood leukocytes.

Long Name

Wiskott-Aldrich Syndrome Protein Family Member 1

Alternate Names

SCAR1, WASP1, WAVE1

Gene Symbol

WASF1

Additional WASF1/WAVE1 Products

Product Documents for WASF1/WAVE1 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for WASF1/WAVE1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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