XPV/DNA polymerase eta Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-87165

Novus Biologicals, part of Bio-Techne
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NBP1-87165
NBP1-87165-25ul
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Key Product Details

Species Reactivity

Human

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all XPV Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: PPLTMLFLCATKFSASAPSSSTDITSFLSSDPSSLPKVPVTSSEAKTQGSGPAVTATKKATTSLESFFQKAAERQKVKEASLSSLTAPTQAPMSNSPSKPSLPFQTSQSTGTE

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for XPV/DNA polymerase eta Antibody

Immunocytochemistry/ Immunofluorescence: XPV/DNA polymerase eta Antibody [NBP1-87165]

Immunocytochemistry/ Immunofluorescence: XPV/DNA polymerase eta Antibody [NBP1-87165]

Immunocytochemistry/Immunofluorescence: XPV/DNA polymerase eta Antibody [NBP1-87165] - Staining of human cell line U-2 OS shows localization to nucleoplasm & cytosol. Antibody staining is shown in green.
Immunohistochemistry-Paraffin: XPV/DNA polymerase eta Antibody [NBP1-87165]

Immunohistochemistry-Paraffin: XPV/DNA polymerase eta Antibody [NBP1-87165]

Immunohistochemistry-Paraffin: XPV/DNA polymerase eta Antibody [NBP1-87165] - Staining of human lymph node shows moderate cytoplasmic and nuclear positivity in germinal center cells.

Applications for XPV/DNA polymerase eta Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml

Immunohistochemistry

1:50 - 1:200

Immunohistochemistry-Paraffin

1:50 - 1:200
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. ICC/IF Fixation Permeabilization: Use PFA/Triton X-100.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: XPV

DNA polymerase eta is specifically involved in DNA repair. It plays an important role in translesion synthesis, where the normal high fidelity DNA polymerases cannot proceed and DNA synthesis stalls. It also plays an important role in the repair of UV-induced pyrimidine dimers. Depending on the context, it inserts the correct base, but causes frequent base transitions and transversions. It targets POLI to replication foci (referenced from swissprot).

Long Name

Xeroderma Pigmentosum Variant Type Protein

Alternate Names

DNA Polymerase, eta, POLH, RAD30A

Gene Symbol

POLH

Additional XPV Products

Product Documents for XPV/DNA polymerase eta Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for XPV/DNA polymerase eta Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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