ZNF198 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-84685

Novus Biologicals, part of Bio-Techne
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NBP1-84685
NBP1-84685-25ul
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Key Product Details

Validated by

Orthogonal Validation

Species Reactivity

Validated:

Human

Predicted:

Mouse (98%), Rat (98%). Backed by our 100% Guarantee.

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all ZNF198 Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: RLSFGTVFRHWKKNPLTMENKACLRYQVSSLCGTDNEDKITTGKRKHEDDEPVFEQIENTANPSRCPVKMFECYLSKSPQN

Reactivity Notes

Reactivity reported in scientific literature (PMID: 23435261)

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for ZNF198 Antibody

Immunocytochemistry/ Immunofluorescence: ZNF198 Antibody [NBP1-84685]

Immunocytochemistry/ Immunofluorescence: ZNF198 Antibody [NBP1-84685]

Immunocytochemistry/Immunofluorescence: ZNF198 Antibody [NBP1-84685] - Staining of human cell line A-431 shows localization to nucleoplasm & endoplasmic reticulum.
Immunohistochemistry-Paraffin: ZNF198 Antibody [NBP1-84685]

Immunohistochemistry-Paraffin: ZNF198 Antibody [NBP1-84685]

Immunohistochemistry-Paraffin: ZNF198 Antibody [NBP1-84685] - Staining of human liver shows very weak positivity in hepatocytes.
Immunohistochemistry-Paraffin: ZNF198 Antibody [NBP1-84685]

Immunohistochemistry-Paraffin: ZNF198 Antibody [NBP1-84685]

Immunohistochemistry-Paraffin: ZNF198 Antibody [NBP1-84685] - Staining of human testis shows strong nuclear positivity in cells of seminiferus ducts.
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Applications for ZNF198 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml

Immunohistochemistry

1:50 - 1:200

Immunohistochemistry-Paraffin

1:50 - 1:200
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. Immunocytochemistry/Immunofluorescence Fixation Permeabilization: Use PFA/Triton X-100.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: ZNF198

Official Gene Symbol: ZMYM2 Gen Bank Accession Number: NP_932072 Gene ID: 7750 (Human) Gene Map Locus: 13q11-q12 (Human) ZNF198 is a ubiquitously expressed nuclear protein whose physiological role is largely unknown. It consists of 5 N-terminal zinc finger motifs responsible for protein-protein interactions, a central proline-rich domain and C-terminal nuclear localization signal (NLS) and an acidic domain. Reciprocal chromosomal translocation involving ZNF198 and FGFR1 results in the formation of ZNF198/FGFR1 fusion kinase protein. This fusion protein is a ligand-dependent, constitutively active cytoplasmic tyrosine kinase and regulates several STAT transcription factors including STAT 1, 3 and 5. This fusion protein is an oncogenic protein and is associated with an atypical myeloproliferative disease, peripheral blood eosinophilia and T-cell leukemia/lymphoma.

Alternate Names

FIMRAMPSCLL, Fused in myeloproliferative disorders protein, MYM, Rearranged in atypical myeloproliferative disorder protein, Zinc finger protein 198rearranged in an atypical myeloproliferative disorder, zinc finger, MYM-type 2, ZNF198zinc finger MYM-type protein 2

Gene Symbol

ZMYM2

Additional ZNF198 Products

Product Documents for ZNF198 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for ZNF198 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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