CELT-133

CELT-133 is a selective hα_1A adrenergic receptor fluorescent antagonist. It shows full selectivity for α_1A over α_2A (K_i= 5 nM and 15% of displacement at 1 μM respectively in radioligand binding assay). CELT-133 binds equally to all subtypes of α₁ adrenergic receptor. Excitation and emission maxima (λ) are 560 and 571 nm, respectively. Wavelengths are compatible with use as an acceptor dye in TR-FRET assays, together with the CoraFluor™ 1 (Cat. No. 7920) TR-FRET donor.

Add 76 μL of assay buffer containing 1% of DMSO to obtain a 100 μM stock solution, and use 250 nM as a working concentration.

Sold under license from Celtarys Research