HMG-CoA Reductase/HMGCR 293T Cell Transient Overexpression Lysate

Name: HMG-CoA Reductase/HMGCR 293T Cell Transient Overexpression Lysate
Brand: Novus Biologicals
SKU: H00003156-T01

Novus Biologicals, part of Bio-Techne | Catalog # H00003156-T01

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Product Datasheet / COA

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Product Summary
Product Specifications
Scientific Data
Preparation & Storage
Background
Product Documents
Specific Notices

Key Product Details

Species

Human

Applications

Western Blot

Product Summary for HMG-CoA Reductase/HMGCR 293T Cell Transient Overexpression Lysate

Quality control test: Transient overexpression cell lysate was tested with Anti-HMGCR antibody by Western Blots. Plasmid: pCMV-HMGCR full-length

Product Specifications

Specificity

HMG-CoA Reductase/HMGCR 293T Cell Transient Overexpression Lysate(Denatured)

Type

293T Cell Transient Overexpression

Protein State

Denatured

Scientific Data Images for HMG-CoA Reductase/HMGCR 293T Cell Transient Overexpression Lysate

Other: HMG-CoA Reductase/HMGCR 293T Cell Transient Overexpression Lysate [H00003156-T01]

HMGCR transfected lysate.

Lane 1: HMGCR transfected lysate (91.96 KDa) Lane 2: Non-transfected lysate.

Formulation, Preparation, and Storage

Formulation

1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)

Concentration

mg/ml

Shipping

The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at -80C. Avoid freeze-thaw cycles.

Background: HMG-CoA Reductase/HMGCR

HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Long Name

3-Hydroxy-3-Methylglutaryl-CoA Reductase

Alternate Names

HMGCR, Hydroxymethylglutaryl-CoA Reductase, LDLCQ3

Gene Symbol

HMGCR

Additional HMG-CoA Reductase/HMGCR Products

Product Documents for HMG-CoA Reductase/HMGCR 293T Cell Transient Overexpression Lysate

Product Datasheets

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COA

Product Specific Notices for HMG-CoA Reductase/HMGCR 293T Cell Transient Overexpression Lysate

This product is produced by and distributed for Abnova, a company based in Taiwan.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Lysates are guaranteed for 6 months from date of receipt.

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