Recombinant Human ASC2 GST Protein

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-18157

Novus Biologicals, part of Bio-Techne
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NBP3-18157
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Key Product Details

Source

E. coli

Accession #

Q8WXC3

Tag

GST

Conjugate

Unconjugated

Applications

SDS-PAGE

View all ASC2 Proteins and Enzymes »

Product Specifications

Description

Human ASC2 (aa 2-89) fused at the N-terminus to a GST tag.

Source: E. coli

Uniprot ID: Q8WXC3

Purity

>95% pure by SDS-PAGE

Predicted Molecular Mass

38 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Protein / Peptide Type

Recombinant Protein

Formulation, Preparation and Storage

NBP3-18157
Formulation Lyophilized from PBS
Preservative No Preservative
Concentration Lyoph
Reconstitution Reconstitute with 100 ul sterile water (0.1mg/ml after reconstitution)
Shipping The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: ASC2

ASC2/POP1 is a PAAD domain only protein originally identified in a bioinformatics screen aimed at understanding molecular apoptosis mechanisms (Pawtokski et al, 2001; reviewed in Fabiola et al, 2006, and Mariathasan and Vuvic, 2003.). ASC2/POP1 has high amino acid sequence homology with ASC (64%), hence it was originally termed ASC2. The PAAD (also known as PYRIN) domain is a conserved sequence motif identified in more than 35 human proteins with putative functions in apoptosis and inflammatory signaling pathways. PAAD was named after the protein families from which it was discovered: pyrin, AIM (absent-in-melanoma), ASC [apoptosis-associated speck-like protein containing a caspase recruitment domain (CARD], and death-domain (DD)-like. PAAD is thought to function as a protein-protein interaction domain, possibly coupling different signaling pathways such as apoptosis, inflammation and cancer. For example, PAADs are capable of homotypic interactions with themselves or other members of the PAAD family, suggesting that they participate in complex protein-interaction networks that link various signalling pathways. In humans, the gene encoding ASC2/POP1 is on chromosome 16p12.1, only 14 kbp away from the ASC locus. The close proximity of ASC2/POP1 to ASC as well as the high sequence homology between them suggest that the ASC2/POP1 and ASC genes arose by gene duplication. Studies have shown that ASC2/POP1 associates with ASC via PADD-PADD interactions and modulates ASC-mediated roles in apoptosis and inflammation. ASC2/POP1 may also have a role in modulating other multidomain PAAD-containing proteins. However, the physiological relevance of ASC2/POP1 remains to be fully elucidated. Human ASC2/POP1 is an 89 amino acid protein and migrates at ~10-12 kDa on SDS-PAGE gels (Stehlik et al, 2003).

Alternate Names

ASC2PAAD-only protein 1, ASCI, POP1pyrin domain-containing protein 1, PYC1, PYD (pyrin domain) containing 1, pyrin domain containing 1, pyrin-domain containing protein 1, Pyrin-only protein 1

Gene Symbol

PYDC1

UniProt

Q8WXC3 (Human)

Additional ASC2 Products

Product Documents for Recombinant Human ASC2 GST Protein

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Recombinant Human ASC2 GST Protein

This product is for research use only and is not approved for use in humans or in clinical diagnosis. This product is guaranteed for 1 year from date of receipt.

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