BAK L to A BH3 Synthetic Peptide GQVGRQAAIIGDDINR, CF

R&D Systems, part of Bio-Techne | Catalog # 879-BK

R&D Systems, part of Bio-Techne
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879-BK-100
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Key Product Details

Source

Synthetic

Accession #

Q16611

Conjugate

Unconjugated

Applications

Inhibition Activity

View all BAK Proteins and Enzymes »

Product Specifications

N-terminal Sequence Analysis

Gly72

Predicted Molecular Mass

1.7 kDa

Formulation, Preparation and Storage

879-BK
Reconstitution Reconstitute in 20 μL of DMSO to obtain a 3.0 mM concentration.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Background: BAK

Bcl-2-antagonist/killer (BAK), also known as BAK1 and Bcl-2-like Protein 7, is a proaptoptotic member of the Bcl-2 protein family with a predicted molecular weight of approximately 23 kDa. It contains four Bcl-2 homology domains, BH1-BH4, and a C-terminal transmembrane domain. Human BAK shares 77% amino acid sequence identity with the mouse and rat orthologs. BAK primarily localizes to the outer mitochondrial membrane where it is redundantly required, along with Bax, for the release of Cytochrome c during apoptosis. Cytochrome c release may occur through pores formed by homo-oligomerization of BAK within the mitochondrial outer membrane. BAK can be directly activated by BID, BIM, and PUMA, which are also members of the Bcl-2 family. Additionally, p53 can directly activate BAK in response to cell stress. BAK may also be involved in crosstalk between the apoptosis and autophagy pathways.

Long Name

Bcl-2 Antagonist/Killer

Alternate Names

BAK1, BCL2L7

Entrez Gene IDs

578 (Human); 12018 (Mouse)

Gene Symbol

BAK1

UniProt

Q16611 (Human)

Additional BAK Products

Product Documents for BAK L to A BH3 Synthetic Peptide GQVGRQAAIIGDDINR, CF

Product Datasheets

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Product Specific Notices for BAK L to A BH3 Synthetic Peptide GQVGRQAAIIGDDINR, CF

For research use only

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