Recombinant Mouse beta-Synuclein Active, Monomer Protein

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-14776

Novus Biologicals, part of Bio-Techne
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Key Product Details

Conjugate

Unconjugated

Applications

SDS-PAGE, Western Blot

View all beta-Synuclein Proteins and Enzymes »

Product Specifications

Description

A full length recombinant protein of Mouse beta-Synuclein

Source: E. coli

Uniprot ID: Q91ZZ3

Purity

>95%, by SDS-PAGE

Localization

Cytoplasm

Protein / Peptide Type

Recombinant Protein

Scientific Data Images for Recombinant Mouse beta-Synuclein Active, Monomer Protein

SDS-PAGE: Recombinant Mouse beta-Synuclein Active, Monomer Protein [NBP3-14776]

SDS-PAGE: Recombinant Mouse beta-Synuclein Active, Monomer Protein [NBP3-14776]

SDS-Page: Recombinant Mouse beta-Synuclein Active, Monomer Protein [NBP3-14776] - Coomassie gel stain of Mouse Beta Synuclein Monomer (NBP3-14776). Load: 2 ug.

Formulation, Preparation and Storage

NBP3-14776
Preparation Method Ion-exchange Purified
Formulation PBS pH 7.4
Preservative No Preservative
Concentration Please see the vial label for concentration. If unlisted please contact technical services.
Shipping The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Store at -80C. Avoid freeze-thaw cycles.

Background: beta-Synuclein

Alpha synuclein is an abundant 140 amino acid neuronal protein, expressed primarily at presynaptic terminals in the central nervous system. Alpha synuclein has been associated with several neurodegenerative diseases. A point mutation in the gene coding for the alpha-synuclein protein was the first discovery linking this protein to a rare familial form of Parkinson's disease (PD). Subsequently, other mutations in the alpha-synuclein gene have been identified in familial PD. The aggregated proteinaceous inclusions called Lewy bodies found in PD and cortical Lewy body dementia (LBD) were discovered to be predominantly alpha-synuclein. Aberrant aggregation of alpha-synuclein has been detected in an increasing number of neurodegenerative diseases, collectively known as synucleopathies. Alpha-synuclein exists physiologically in both soluble and membrane-bound states, in unstructured and alpha-helical conformations, respectively. The physiological function of alpha-synuclein appears to require its translocation between these subcellular compartments and interconversion between the 2 conformations. Abnormal processing of alpha-synuclein is predicted to lead to pathological changes in its binding properties and function (1).

Alternate Names

SNCB, Synuclein-beta

Gene Symbol

SNCB

Additional beta-Synuclein Products

Product Documents for Recombinant Mouse beta-Synuclein Active, Monomer Protein

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Recombinant Mouse beta-Synuclein Active, Monomer Protein

Please note that the 200ug and 500ug sizes are sent in 2x100ug and 5x100ug vials, respectively

This product is for research use only and is not approved for use in humans or in clinical diagnosis. This product is guaranteed for 1 year from date of receipt.

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