Recombinant Human beta-Synuclein Active, Pre-formed Fibrils, (Type 1) Protein

Name: Recombinant Human beta-Synuclein Active, Pre-formed Fibrils, (Type 1) Protein
Brand: Novus Biologicals
SKU: NBP3-14777

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-14777

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Product Specifications
Scientific Data
Preparation & Storage
Background
Product Documents
Specific Notices

Key Product Details

Conjugate

Unconjugated

Applications

Microscopy, Functional Assay, SDS-PAGE, Western Blot

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Product Specifications

Description

A full length recombinant protein of Human beta-Synuclein

Source: E. coli

Uniprot ID: Q16143

Purity

>95%, by SDS-PAGE

Localization

Cytoplasm

Protein / Peptide Type

Recombinant Protein

Scientific Data Images

Electron Microscopy: Recombinant Human beta-Synuclein Active, Pre-formed Fibrils, (Type 1) Protein [NBP3-14777] - TEM of Active Human Recombinant Beta Synuclein Protein Pre-formed Fibrils (Type 1) (NBP3-14777)

Formulation, Preparation and Storage

NBP3-14777

Preparation Method	Ion-exchange Purified
Formulation	PBS pH 7.4
Preservative	No Preservative
Concentration	Please see the vial label for concentration. If unlisted please contact technical services.
Shipping	The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage	Store at -80C. Avoid freeze-thaw cycles.

Background: beta-Synuclein

Alpha synuclein is an abundant 140 amino acid neuronal protein, expressed primarily at presynaptic terminals in the central nervous system. Alpha synuclein has been associated with several neurodegenerative diseases. A point mutation in the gene coding for the alpha-synuclein protein was the first discovery linking this protein to a rare familial form of Parkinson's disease (PD). Subsequently, other mutations in the alpha-synuclein gene have been identified in familial PD. The aggregated proteinaceous inclusions called Lewy bodies found in PD and cortical Lewy body dementia (LBD) were discovered to be predominantly alpha-synuclein. Aberrant aggregation of alpha-synuclein has been detected in an increasing number of neurodegenerative diseases, collectively known as synucleopathies. Alpha-synuclein exists physiologically in both soluble and membrane-bound states, in unstructured and alpha-helical conformations, respectively. The physiological function of alpha-synuclein appears to require its translocation between these subcellular compartments and interconversion between the 2 conformations. Abnormal processing of alpha-synuclein is predicted to lead to pathological changes in its binding properties and function (1).

Alternate Names

SNCB, Synuclein-beta

Gene Symbol

SNCB

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Product Specific Notices

Please note that the 200ug and 500ug sizes are sent in 2x100ug and 5x100ug vials, respectively

This product is for research use only and is not approved for use in humans or in clinical diagnosis. This product is guaranteed for 1 year from date of receipt.

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