Recombinant Canine C-Reactive Protein/CRP Protein

Name: Recombinant Canine C-Reactive Protein/CRP Protein
Brand: Novus Biologicals
SKU: NBP2-62429

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-62429

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Product Specifications
Preparation & Storage
Background
Product Documents
Specific Notices

Key Product Details

Conjugate

Unconjugated

Applications

ELISA

View all C-Reactive Protein/CRP Proteins and Enzymes »

Product Specifications

Description

Recombinant dog C-reactive protein

Source:Eukaryotic expression system

Amino Acid Sequence: 204 aa, UniProt T2KEN6

Purity

Affinity purified

Predicted Molecular Mass

114 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Protein / Peptide Type

Recombinant Protein

Formulation, Preparation and Storage

NBP2-62429

Formulation	TRIS buffered saline, 2 mM CaCl2
Preservative	No Preservative
Concentration	Lyoph
Reconstitution	Reconstitute with 1 ml distilled water. Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. Gently mix vial after reconstitution
Shipping	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage	Store at -20C. Avoid freeze-thaw cycles.

Background: C-Reactive Protein/CRP

C Reactive Protein is a major acute phase reactant synthesized primarily in the liver hepatocytes. It is a pentraxin (cyclic pentameric protein) compound of five identical nonglycosylated subunits of 206 amino acids each (m.w. 24 kDa), that are bound noncovalently to form the physiologic CRP molecule (m.w. 117.5 kDa). C Reactive Protein mediates activities associated with preimmune nonspecific host resistance. It is opsonic, an initiator of the classical complement cascade and an activator of monocytes/macrophages. CRP also binds to several nuclear components including chromatin, histones and snRNP, suggesting that it may play a role as a scavenger during cell necrosis. Studies have revealed that among other markers of inflammation, CRP shows the strongest association with cardiovascular events. Many clinical studies demonstrated that coronary mortality among patients with unstable angina and elevated CRP is significantly higher comparing with the patients without elevated CRP. Measurements of C reactive protein (hsCRP) in the patients with ischemic heart disease provide a novel method for detecting individuals at high risk of plaque rupture.

Alternate Names

CRP

Gene Symbol

CRP

Additional C-Reactive Protein/CRP Products

Product Documents for Recombinant Canine C-Reactive Protein/CRP Protein

Product Datasheets

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COA

Product Specific Notices for Recombinant Canine C-Reactive Protein/CRP Protein

This product is for research use only and is not approved for use in humans or in clinical diagnosis. This product is guaranteed for 1 year from date of receipt.

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