CRTH-2/GPR44 Antibody Blocking Peptide

Name: CRTH-2/GPR44 Antibody Blocking Peptide
Brand: Novus Biologicals
SKU: NBP1-76755PEP

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-76755PEP

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Product Specifications
Scientific Data
Preparation & Storage
Background
Product Documents
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Key Product Details

Source

Synthetic

Conjugate

Unconjugated

Applications

Antibody Competition

View all CRTH-2 Proteins and Enzymes »

Product Specifications

Description

A blocking peptide containing 18 amino acid peptide from near the amino terminus of human CRTH2.

Source: Synthetic

(Accession #: NP_004769)

Purity

N/A

Application Notes

This peptide is useful as a blocking peptide for NBP1-76755. For further blocking peptide related protocol, click here.

Protein / Peptide Type

Antibody Blocking Peptide

Scientific Data Images for CRTH-2/GPR44 Antibody Blocking Peptide

Western Blot: CRTH-2/GPR44 Antibody Blocking Peptide [NBP1-76755PEP]

Western Blot: GPR44 Peptide [NBP1-76755PEP] - blocks the antibody activity completely in Western blot by incubating the peptide with equal volume of antibody for 30 min at 37C.

Formulation, Preparation and Storage

NBP1-76755PEP

Formulation	PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin.
Preservative	0.02% Sodium Azide
Concentration	0.2 mg/ml
Shipping	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage	Store at -20C. Avoid freeze-thaw cycles.

Background: CRTH-2

GPR44, also called CRTH2, is a Prostanoid Receptor that binds prostaglandin D2. PGD2 signals through CRTH2 to induce Th2, eosinophil, and basophil chemotaxis in a G-alpha(i) dependent manner. CRTH2 may play a role in mast cell-mediated immune responses such as those involved in allergic reactions. This receptor is upregulated in activated T helper-2 (Th2) cells, peripheral blood basophils, and eosinophils, but not in Th1 lineage cells. It may be a useful marker for Th2 and Tc2 cells. CRTH2 has been reported to be expressed in the central nervous system, peripheral tissues, and in blood cells, particularly activated T helper-2 cells. Two transcripts have been isolated, a 3.5-kb transcript expressed primarily in the thalamus, frontal cortex, pons, and hippocampus, and a 3.4-kb transcript expressed in fetal liver, leukocytes, and thymus. ESTs have been isolated from B-cell/lung/testis, brain, kidney, liver/spleen, placenta, prostate, testis, and thymus libraries.

Long Name

Chemoattractant Receptor-homologous Molecule Expressed on Th2 Cells

Alternate Names

CD294, CRTH2, GPR44, PGD2R, PTGDR2

Gene Symbol

PTGDR2

Additional CRTH-2 Products

Product Documents for CRTH-2/GPR44 Antibody Blocking Peptide

Product Datasheets

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COA

SDS

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Product Specific Notices for CRTH-2/GPR44 Antibody Blocking Peptide

This product is for research use only and is not approved for use in humans or in clinical diagnosis. This product is guaranteed for 1 year from date of receipt.

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