Recombinant Human CXCL11/I-TAC Protein

Name: Recombinant Human CXCL11/I-TAC Protein
Brand: Novus Biologicals
SKU: NBP2-34922

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-34922

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Product Datasheet / COA

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Product Specifications
Scientific Data
Preparation & Storage
Background
Product Documents
Specific Notices

Key Product Details

Source

E. coli

Accession #

O14625

Conjugate

Unconjugated

Applications

Bioactivity, SDS-PAGE

View all CXCL11/I-TAC Proteins and Enzymes »

Product Specifications

Description

A single non-glycosylated polypeptide chain containing 73 amino acids corresponding to CXCL11/I-TAC Source: E. coli

Uniprot ID: O14625

Amino Acid Sequence: FPMFKRGRCL CIGPGVKAVK VADIEKASIM YPSNNCDKIE VIITLKENKG QRCLNPKSKQ ARLIIKKVER KNF

Purity

> 97 % pure by SDS-PAGE and HPLC

Endotoxin Level

Less than 1 EU/ug of CXCL11/I-TAC as determined by LAL method.

Predicted Molecular Mass

8.3 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Activity

CXCL11 Protein is fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human IL-2 activated human T-lymphocytes is in a concentration range of 0.1-10 ng/ml.

Protein / Peptide Type

Recombinant Protein

Scientific Data Images for Recombinant Human CXCL11/I-TAC Protein

SDS-PAGE: Recombinant Human CXCL11/I-TAC Protein [NBP2-34922]

SDS-Page: Human CXCL11/I-TAC Protein [NBP2-34922]

Formulation, Preparation and Storage

NBP2-34922

Formulation	Lyophilized from a 0.2 um filtered concentrated solution in 20 mM PB, pH 7.4, 100 mM NaCl.
Preservative	No Preservative
Concentration	Lyoph
Reconstitution	Recommended to centrifuge prior to opening. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0mg/mL.
Format	Carrier-Free
Shipping	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage	Store at -20 to -70C as supplied. After reconstitution, store at 2 to 8C for 1 month and at -20 to -70C for long term storage. Avoid repeated freeze-thaw cycles.

Background: CXCL11/I-TAC

CXCL11 also known as I-TAC is belonging to the CXC chemokine family and shares 36 % and 37 % amino acid sequence homology with IP-10 and MIG, respectively. It is highly expressed in peripheral blood leukocytes, pancreas and liver. Expression of CXCL11 is strongly induced by IFN-gamma and IFN-beta, and weakly induced by IFN-alpha. This chemokine elicits its effects by binding to the cell surface chemokine receptor CXCR3, which with a higher affinity than do the other chemokines for this receptor, CXCL9 and CXCL10. Similar to CXCL10, CXCL11 has been shown to be a chemoattractant for IL-2-activated T-lymphocytes, but not for isolated T-cells, neutrophils or monocytes

Alternate Names

beta-R1, H174, I-TAC, ITAC, SCYB9B, I-TAC/CXCL11

Gene Symbol

CXCL11

UniProt