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Recombinant Exendin-4 Protein

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-34945

Novus Biologicals, part of Bio-Techne
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NBP2-34945-100ug
NBP2-34945-1mg
NBP2-34945-500ug

Key Product Details

Source

E. coli

Conjugate

Unconjugated

Applications

Bioactivity, SDS-PAGE

Product Specifications

Description

A single non-glycosylated polypeptide chain containing 39 amino acids corresponding to Exendin-4 Source: E. coli

Uniprot ID: P26349

Amino Acid Sequence: HGEGTFTSDL SKQMEEEAVR LFIEWLKNGG PSSGAPPPS

Purity

>95%, by SDS-PAGE and HPLC

Endotoxin Level

Less than 10 EU/mg of Exendin-4 as determined by LAL method.

Predicted Molecular Mass

4.2 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Activity

1. Regulates Glucose levels rapidly;
2. Reduces Insulin resistance;
3. Reduces Glucagon;
4. Reduces HbA1c;
5. Stimulates beta cell growth which stimulates insulin production.

Protein / Peptide Type

Recombinant Protein

Scientific Data Images for Recombinant Exendin-4 Protein

SDS-PAGE: Recombinant Exendin-4 Protein [NBP2-34945]

SDS-PAGE: Recombinant Exendin-4 Protein [NBP2-34945]

SDS-Page: Recombinant Reptile Exendin-4 Protein [NBP2-34945] - Exendin-4 Protein [NBP2-34945]

Formulation, Preparation and Storage

NBP2-34945
Formulation Lyophilized from a 0.2 um filtered solution in PBS, pH 7.4.
Preservative No Preservative
Concentration Lyoph
Reconstitution Recommended to centrifuge prior to opening. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0mg/mL.
Format Carrier-Free
Shipping The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Store at -20 to -70C as supplied. After reconstitution, store at 2 to 8C for 1 month and at -20 to -70C for long term storage. Avoid repeated freeze-thaw cycles.

Background: Exendin-4

Exendin-4 is a novel 39-amino acid peptide isolated from the venom of the Gila monster Heloderma suspectum. It shares 53 % sequence homology with GLP-17-36amide and interacts with the same membrane receptor. Exendin-4 enhances glucosedependent insulin secretion, suppresses inappropriately elevated glucagon secretion, and slows gastric emptying in vivo. It also promotes beta-cell proliferation and neogenesis in vitro and in animal models. Recombinant Exendin-4 is E. coli expression of a synthetic DNA sequence encoding the 39 amino acid of Exendin-4.

Alternate Names

Exendin4

Additional Exendin-4 Products

Product Documents for Recombinant Exendin-4 Protein

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for Recombinant Exendin-4 Protein

This product is for research use only and is not approved for use in humans or in clinical diagnosis. This product is guaranteed for 1 year from date of receipt.

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