Recombinant Human FGF-17 Protein

Name: Recombinant Human FGF-17 Protein
Brand: Novus Biologicals
SKU: NBP2-61312

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-61312

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Product Datasheet / COA

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Product Specifications
Scientific Data
Preparation & Storage
Background
Product Documents
Specific Notices

Key Product Details

Source

E. coli

Conjugate

Unconjugated

Applications

Bioactivity, Western Blot

View all FGF-17 Proteins and Enzymes »

Product Specifications

Description

A single non-glycosylated polypeptide chain containing 195 amino acids corresponding to FGF-17 Source: E. coli

Uniprot ID: O60258

Amino Acid Sequence: MTQGENHPSP NFNQYVRDQG AMTDQLSRRQ IREYQLYSRT SGKHVQVTGR RISATAEDGN KFAKLIVETD TFGSRVRIKG AESEKYICMN KRGKLIGKPS GKSKDCVFTE IVLENNYTAF QNARHEGWFM AFTRQGRPRQ ASRSRQNQRE AHFIKRLYQG QLPFPNHAEK QKQFEFVGSA PTRRTKRTRR PQPLT

Purity

>95%, by SDS-PAGE and HPLC

Endotoxin Level

Less than 0.1 EU/ug of FGF-17 as determined by LAL method.

Predicted Molecular Mass

22.6 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Activity

FGF-17 protein is fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine balb/c 3T3 cells is less than 10 ng/ml, corresponding to a specific activity of >1.0 x 10^5 IU/mg.

Protein / Peptide Type

Recombinant Protein

Scientific Data Images for Recombinant Human FGF-17 Protein

SDS-PAGE: Recombinant Human FGF-17 Protein [NBP2-61312]

SDS-Page: Recombinant Human FGF-17 Protein [NBP2-61312]

Formulation, Preparation and Storage

NBP2-61312

Formulation	Lyophilized from a 0.2 um filtered concentrated solution in PBS, pH 7.4.
Preservative	No Preservative
Concentration	Lyoph
Reconstitution	Recommended to centrifuge prior to opening. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0mg/mL. Apportion stock solutions into working aliquots and store at
Shipping	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage	Store at -20 to -70C as supplied. After reconstitution, store at 2 to 8C for 1 month and at -20 to -70C for long term storage. Avoid repeated freeze-thaw cycles.

Background: FGF-17

The FGF17 gene codes for a fibroblast growth factor 17 protein that in isoform 1 is 216 amino acids long at 24 kDA and in isoform 2 is 205 amino acids long at 23 kDA. This gene is a member of the fibroblast growth factor (FGF) family so is thought to participate in nervous system development and function, specifically in embryonic development as well as a signaling molecule in the induction and patterning of the embryonic brain. FGF14 is involved in regulation of actin cytoskeleton, MAPK signaling, signaling by FGFR and FGFR mutants, as well as downstream signal transduction. It interacts with genes EGFR, FGFR1, FGFR2, FGFR3, and FGFR4. FGF14 is associated with pancreatitis, breast cancer, leukemia, melanoma, and adenocarcinoma.

Long Name

Fibroblast Growth Factor 17

Alternate Names

FGF17

Gene Symbol