GFR alpha-2/GDNF R alpha-2 Antibody Blocking Peptide

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-77042PEP

Novus Biologicals, part of Bio-Techne
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NBP1-77042PEP
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Key Product Details

Source

Synthetic

Conjugate

Unconjugated

Applications

Antibody Competition

View all GFR alpha-2/GDNF R alpha-2 Proteins and Enzymes »

Product Specifications

Description

A blocking peptide containing 15 amino acids near the center of human GFR alpha-2/GDNF R alpha-2.

Source: Synthetic

(Accession #: AAC52036)

Purity

N/A

Application Notes

This peptide is useful as a blocking peptide for NBP1-77042. For further blocking peptide related protocol, click here.

Protein / Peptide Type

Antibody Blocking Peptide

Formulation, Preparation and Storage

NBP1-77042PEP
Formulation PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin.
Preservative 0.02% Sodium Azide
Concentration 0.2 mg/ml
Shipping The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Store at -20C. Avoid freeze-thaw cycles.

Background: GFR alpha-2/GDNF R alpha-2

Members of the glial cell line derived neurotrophic factor (GDNF) family, including GDNF and neurturin (NTN), play key roles in the control of vertebrate neuron survival and differentiation. Physiological responses to NTN require the presence of a novel glycosylphosphadidylinositol linked protein NTNRa, which is a cell surface receptor for NTN. The cDNAs encoding NTNRa from human, rat, chicken, and mouse have been cloned recently. NTNRa was also termed GDNFRb, Ret ligand 2 (RETL2) or TGFb related neurotrophic factor receptor 2 (TrnR2) and nominated as GFRa2 recently. GFRa2 binds NTN and mediates activation of RET receptor tyrosine kinase by both NTN and GDNF. Thus, NTN, GFRa2, and the Ret PTK form a complex to transduce NTN signal and to mediate NTN function.

Long Name

Glial Cell line-derived Neurotrophic Factor Receptor alpha 2

Alternate Names

GDNF R alpha-2, GFR alpha2, GFRa-2, GFRA2

Gene Symbol

GFRA2

Additional GFR alpha-2/GDNF R alpha-2 Products

Product Documents for GFR alpha-2/GDNF R alpha-2 Antibody Blocking Peptide

Product Datasheets

Certificate of Analysis

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Product Specific Notices for GFR alpha-2/GDNF R alpha-2 Antibody Blocking Peptide

This product is for research use only and is not approved for use in humans or in clinical diagnosis. This product is guaranteed for 1 year from date of receipt.

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