Neurofibromin 1 Antibody Blocking Peptide

Name: Neurofibromin 1 Antibody Blocking Peptide
Brand: Novus Biologicals
SKU: NB300-155PEP

Novus Biologicals, part of Bio-Techne | Catalog # NB300-155PEP

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Product Specifications
Preparation & Storage
Background
Product Documents
Specific Notices

Key Product Details

Conjugate

Unconjugated

Applications

Antibody Competition

View all Neurofibromin 1 Proteins and Enzymes »

Product Specifications

Description

A NF1 antibody blocking peptide.

Application Notes

This peptide is useful as a blocking peptide for NB300-155. For further blocking peptide related protocol, click here.

Specificity

This peptide is specific for NB300-155 only.

Protein / Peptide Type

Antibody Blocking Peptide

Formulation, Preparation and Storage

NB300-155PEP

Preservative	No Preservative
Concentration	1.0 mg/ml
Shipping	The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage	Store at -80C. Avoid freeze-thaw cycles.

Background: Neurofibromin 1

Neurofibromin 1 (NF1), the Nf1 gene product, is a large protein which contains a central Ras-GTPase-activating (RasGAP) domain and is suggested to function as a negative regulator of proto-oncogene RAS and downstream effectors. It stimulates the GTPase activity of RAS and acts as regulator of RAS signaling. Consistent with its biochemical activity, NF1 functions as a tumor-suppressor gene in juvenile myelomonocytic leukemia (JMML), and diseased BM cells exhibit aberrant Raf/MEK/ERK signaling. Moreover, NF1 shows greater affinity for Ras GAP, but lower specific activity. Besides JMML, defects in NF1 have also been linked to neurofibromatosis type 1 (NF1), Watson syndrome (WS), familial spinal neurofibromatosis (FSNF), neurofibromatosis-Noonan syndrome (NFNS), colorectal cancer (CRC).

Alternate Names

DKFZp686J1293, FLJ21220, Neurofibromatosis-related protein NF-1, neurofibromin, neurofibromin 1, NFNS, VRNF, WSS

Gene Symbol

NF1

Additional Neurofibromin 1 Products

Product Documents for Neurofibromin 1 Antibody Blocking Peptide

Product Datasheets

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COA

Product Specific Notices for Neurofibromin 1 Antibody Blocking Peptide

This product is for research use only and is not approved for use in humans or in clinical diagnosis. This product is guaranteed for 1 year from date of receipt.

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