Recombinant Human Active Src Protein, CF
R&D Systems, part of Bio-Techne | Catalog # 4595-KS
Key Product Details
Product Specifications
Source
Spodoptera frugiperda, Sf 9 (baculovirus)-derived human Src protein
N-terminal Sequence Analysis
Using an N-terminal GST tag
SDS-PAGE
83 kDa
Activity
The specific activity of Src was determined to be 100 nmol/min/mg using a synthetic peptide substrate.
Scientific Data Images for Recombinant Human Active Src Protein, CF
Recombinant Human Active Src Protein SDS-PAGE.
The approximate molecular weight is 83 kDa and the purity is > 90%.Formulation, Preparation and Storage
4595-KS
| Formulation | Supplied in 50 mM Tris-HCl (pH 7.5), 150 mM NaCl, 10 mM Glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, and 25% Glycerol. |
| Shipping | The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below. |
| Stability & Storage | This product is stable at ≤ ‑70 °C for up to 1 year from the date of receipt. For optimal storage, aliquot into smaller quantities after centrifugation and store at recommended temperature. Avoid repeated freeze-thaw cycles. |
Background: Src
The Src family belongs to non-receptor tyrosine kinases. Src was originally identified as a transforming protein of the Rous Sarcoma Virus (RSV) that had the enzymatic ability to phosphorylate tyrosine in protein substrates (1). Src is over-expressed and activated in a large number of human malignancies and has been linked to the development of cancer and progression to distant metastases (2). In addition to increasing cell proliferation, a key role of Src in cancer seems to be the ability to promote invasion and motility, functions that might contribute to tumor progression.
References
- Collett, M.S. et al. (1978) Proc. Natl. Acad. Sci. USA 75:2021.
- Jacobs, C. et al. (1983) Cancer Res. 43:1696.
Long Name
v-src Sarcoma [Schmidt-Ruppin A-2] Viral Oncogene Homolog
Alternate Names
ASV, c-Src, RSVgp4
Gene Symbol
SRC
UniProt
Additional Src Products
Product Documents for Recombinant Human Active Src Protein, CF
Product Specific Notices for Recombinant Human Active Src Protein, CF
For research use only
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