Recombinant Human Annexin A13 Protein, CF

R&D Systems, part of Bio-Techne | Catalog # 9417-AN

R&D Systems, part of Bio-Techne
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9417-AN-050
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Key Product Details

Source

E. coli

Accession #

P27216-1

Conjugate

Unconjugated

View all Annexin A13 Proteins and Enzymes »

Product Specifications

Source

E. coli-derived human Annexin A13 protein
Gly2-His316 (Arg86His), with a C-terminal 6-His tag

Purity

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.

Endotoxin Level

<0.10 EU per 1 μg of the protein by the LAL method.

N-terminal Sequence Analysis

Gly2

Predicted Molecular Mass

36 kDa

SDS-PAGE

35 kDa, reducing conditions

Activity

Bioassay data are not available.

Formulation, Preparation and Storage

9417-AN
Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution
Reconstitute at 250 μg/mL in PBS.

Reconstitution Buffer Available:
Size / Price
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Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Annexin A13

Human Annexin A13 (ANXA13), also known as Annexin XIII or Annexin 13, is a 35 kDa member of the Annexin family (1), which are calcium-dependent phospholipid-binding proteins being preferentially located on the cytosolic face of the plasma membrane. The Annexins consist of a unique N-terminal domain followed by a homologous C-terminal core domain containing the phospholipid-binding sites. The C-terminal domain of Annexin A13 is comprised of four 60‑70 aa annexin repeats which form a tightly packed disc known as the Annexin domain. Alternate splicing generates an additional isoform with a 41 amino acid (aa) deletion near the N‑terminus (2). Members of the Annexin family play a role in cytoskeletal interactions, phospholipase inhibition, regulation of cellular growth, and intracellular signal transduction pathways (3, 4). Human Annexin A13 shares approximately 86% and 91% aa sequence identity with mouse and dog Annexin A13 respectively.

References

  1. Wice, B. et al. (1992) J Cell Biol. 116:405.
  2. Turnay, J. et al. (2005) Biochem. J. 389:899.
  3. Gerke, V. et al. (2002) Physiol. Rev. 82:331.
  4. Gerke, V. et al. (2005) Nat. Rev. Mol. Cell Biol. 6:449.

Alternate Names

ANX13, ANXA13, ISA

Entrez Gene IDs

312 (Human); 69787 (Mouse); 362915 (Rat)

Gene Symbol

ANXA13

UniProt

P27216-1

Additional Annexin A13 Products

Product Documents for Recombinant Human Annexin A13 Protein, CF

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Product Specific Notices for Recombinant Human Annexin A13 Protein, CF

For research use only

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