Recombinant Human His6-alpha-Synuclein Protein, CF

alpha-Synuclein is member of a family of small soluble proteins that include also beta-, and gamma-Synuclein. It is predominantly expressed in neurons of the central nervous system in the presynaptic region of nerve terminals, where it cycles between a free, partially unfolded and a helical, membrane-bound form. alpha-Synuclein can self-aggregate in vivo and in vitro, forming various oligomeric species and fibrillar and amorphous aggregates. The fibrils and amyloidal forms of alpha-Synuclein are major components of Lewy bodies and Lewy neurites and have been linked to the pathogenesis of Parkinson’s Disease, Parkinson’s Disease Dementia, and dementia with Lewy bodies. alpha-Synuclein aggregates can be also found associated with amyloid plaques in Alzheirmer’s Disease.