Recombinant Human LYPD8 Fc Chimera Protein, CF

R&D Systems, part of Bio-Techne | Catalog # 9087-C4

R&D Systems, part of Bio-Techne
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9087-C4-050
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Key Product Details

Source

CHO

Accession #

Q6UX82

Structure / Form

Disulfide-linked homodimer

Conjugate

Unconjugated

Applications

Bioactivity

View all LYPD8 Proteins and Enzymes »

Product Specifications

Source

Chinese Hamster Ovary cell line, CHO-derived human LYPD8 protein
Human LYPD8
(Leu20-Asn215)
Accession # Q6UX82		 IEGRMD Human IgG1
(Pro100-Lys330)
N-terminus C-terminus

Purity

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

Endotoxin Level

<0.10 EU per 1 μg of the protein by the LAL method.

N-terminal Sequence Analysis

Leu20

Predicted Molecular Mass

48 kDa

SDS-PAGE

85-100 kDa, reducing conditions

Activity

Measured by its binding ability in a functional ELISA.
When Recombinant Human LYPD8 Fc Chimera is coated at 2 µg/mL, Recombinant Human Galectin‑3 (Catalog # 1154-GA) binds with a typical ED50 = 90-540 ng/mL.

Scientific Data Images for Recombinant Human LYPD8 Fc Chimera Protein, CF

Recombinant Human LYPD8 Fc Chimera Protein Bioactivity

Recombinant Human LYPD8 Fc Chimera Protein Bioactivity

When Recombinant Human LYPD8 Fc Chimera is coated at 2 µg/ml, Recombinant Human Galectin-3 (Catalog # 1154-GA) binds with a typical ED50 of 90-540 ng/mL.

Formulation, Preparation and Storage

9087-C4
Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution
Reconstitute at 500 μg/mL in PBS.

Reconstitution Buffer Available:
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Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: LYPD8

Ly6/PLAUR domain containing 8 (LYPD8), is a GPI-linked protein with structural similarity to the urokinase-type plasminogen activator receptor (uPAR) (1). Mature human LYPD8 contains one uPAR/Ly6 domain and a Ser/Thr/Pro-rich (STP) region that may serve as a target for protease mediated shedding as has been shown for the related C4.4A/LYPD3 molecule (2, 3). Mature human LYPD8 shares 40% amino acid sequence identity with mouse and rat LYPD8.

References

  1. Kong, H.K. and J.H. Park (2012) BMB Rep. 45:595.
  2. Hansen, L.V. et al. (2004) Biochem. J. 380:845.
  3. Esselens, C.W. et al. (2008) Biol. Chem. 389:1075.

Long Name

Ly6/PLAUR Domain-containing Protein 8

Entrez Gene IDs

646627 (Human); 70163 (Mouse); 691259 (Rat)

Gene Symbol

LYPD8

UniProt

Q6UX82

Additional LYPD8 Products

Product Documents for Recombinant Human LYPD8 Fc Chimera Protein, CF

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