Recombinant Human Tau K18/Tau PHF Core Protein, CF

R&D Systems, part of Bio-Techne | Catalog # SP-496

R&D Systems, part of Bio-Techne
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SP-496-100
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Key Product Details

Source

E. coli

Accession #

NP_005901.2

Conjugate

Unconjugated

Applications

Bioactivity

View all Tau Proteins and Enzymes »

Product Specifications

Source

E. coli-derived human Tau protein
Gln244 - Glu372 with a N-terminal Met

Purity

>95%, by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie® Blue stain.

Predicted Molecular Mass

14 kDa

Activity

Concentrations for in vitro assays will depend on experimental conditions and detection methods.

Formulation, Preparation and Storage

SP-496
Formulation Supplied as a solution in PBS.
Shipping The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 6 months from date of receipt, -70 °C as supplied.
  • 3 months, -70 °C under sterile conditions after opening.

Background: Tau

Tau is a microtubule-associated protein expressed primarily in neurons.  Carboxy-terminal domains of Tau associate with and stabilize microtubule structure, while other domains bind to the plasma membrane.  Abnormal Tau phosphorylation may result in the self-assembly of tangles of paired helical and/or straight filaments, which are involved in the pathogenesis of Alzheimer's disease and other neurodegenerative diseases.  Properly folded Tau is highly soluble, but when the protein becomes misfolded it forms insoluble aggregates that can damage cytoplasmic functions, interfere with axonal transport and ultimately lead to cell death.  

References

  1. Billingsley M.L. & Kincaid R.L. (1997)  Biochem. J. 323:577.
  2. Bloom G.S. (2014) JAMA Neurol. 71:505.
  3. Cripps D. et al. (2006) J. Biol. Chem. 281:10825.
  4. Harada A. et al. (1994)  Nature 369:488.
  5. Lei P. et al. (2010)  Int. J. Biochem. Cell Biol. 42:1775.
  6. Shamas S.L. et al. (2015) Nat. Comm. 6:7025.

Long Name

Microtubule-Associated Protein Tau

Alternate Names

MAPT, MSTD, MTBT1, Neurofibrillary tangle protein, PPND

Entrez Gene IDs

4137 (Human); 17762 (Mouse); 29477 (Rat)

Gene Symbol

MAPT

UniProt

NP_005901.2

Additional Tau Products

Product Documents for Recombinant Human Tau K18/Tau PHF Core Protein, CF

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Recombinant Human Tau K18/Tau PHF Core Protein, CF

For research use only

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