Recombinant Human TDP-43/TARDBP Protein, CF

R&D Systems, part of Bio-Techne | Catalog # AP-190

R&D Systems, part of Bio-Techne
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AP-190-100
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Key Product Details

Source

E. coli

Accession #

NP_031401.1

Conjugate

Unconjugated

Applications

Bioactivity

View all TDP-43/TARDBP Proteins and Enzymes »

Product Specifications

Source

E. coli-derived human TDP-43/TARDBP protein

Predicted Molecular Mass

45 kDa

Activity

Typical protein concentration for in vitro use depends on the specific application.

Reviewed Applications

Read 1 review rated 4 using AP-190 in the following applications:

Formulation, Preparation and Storage

AP-190
Formulation Supplied as a solution in HEPES, NaCl, DTT, Glycerol and Urea.
Shipping The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 6 months from date of receipt, -70 °C as supplied.
  • 3 months, -70 °C under sterile conditions after opening.

Background: TDP-43/TARDBP

TDP-43 (TAR DNA binding protein of 43 kDa; gene name TARDBP) is a 414 amino acid (aa) nuclear RNA/DNA binding phosphoprotein that regulates transcription and splicing.  TDP-43 is aberrantly expressed in most forms of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration.  In these cases it is absent from the nucleus and accumulates, along with a truncated 20-28 kDa form, in the Ubiquitin-containing inclusion bodies.  TDP-43 can also influence CFTR exon 9 skipping in cystic fibrosis.  Human TDP-43 is 96% identical to the mouse ortholog.

References

  1. Buratti E. et al. (2001) EMBO J.  20: 1774.
  2. Chen-Plotkin A.S. et al. (2010) Nat. Rev. Neurol.  6: 211.
  3. Johnson B.S. et al. (2009) J. Biol. Chem.  284: 20329.
  4. Strong M.J. et al. (2007) Mol. Cell Neurosci.  35: 320.
 

Long Name

TAR DNA-binding Protein 43

Alternate Names

ALS10, TARDBP, TDP43

Entrez Gene IDs

23435 (Human)

Gene Symbol

TARDBP

UniProt

NP_031401.1

Additional TDP-43/TARDBP Products

Product Documents for Recombinant Human TDP-43/TARDBP Protein, CF

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Recombinant Human TDP-43/TARDBP Protein, CF

For research use only

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