Recombinant Human TLR7 Fc Chimera Protein, CF

R&D Systems, part of Bio-Techne | Catalog # 9567-TR

R&D Systems, part of Bio-Techne
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9567-TR-050
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Key Product Details

Source

CHO

Accession #

Q9NYK1

Structure / Form

Disulfide-linked homodimer

Conjugate

Unconjugated

View all TLR7 Proteins and Enzymes »

Product Specifications

Source

Chinese Hamster Ovary cell line, CHO-derived human TLR7 protein
Human TLR7
(Ala27-Asn839)
Accession # Q9NYK1		 IEGRMD Human IgG1
(Pro100-Lys330)
N-terminus C-terminus

Purity

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

Endotoxin Level

<0.10 EU per 1 μg of the protein by the LAL method.

N-terminal Sequence Analysis

Ala27

Predicted Molecular Mass

120 kDa

SDS-PAGE

122-150 kDa, reducing conditions

Activity

Bioassay data are not available.

Formulation, Preparation and Storage

9567-TR
Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution
Reconstitute at 250 μg/mL in PBS.

Reconstitution Buffer Available:
Size / Price
Qty
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: TLR7

TLR7 (Toll-like receptor 7) is a member of the Toll-like receptor family of innate immune receptors. It is mainly expressed in lung, placenta and spleen and belongs to a new sub-family of the TLRs comprising of TLR7, TLR8, an TLR9 (1, 2). Human TLR7 cDNA encodes a 1049 amino acid (aa) precursor that contains a 26 aa signal sequence, an 813 aa extracellular domain (ECD), a 21 aa transmembrane sequence, and a 189 aa cytoplasmic domain. Mature human TLR7 is 81% aa identical to mature mouse TLR7. Human TLR7 is located in the endosomes and involved in the sequence-dependent sensing of single-stranded RNA, thereby detecting bacterial or viral nucleic acids (3, 4, 5).

References

  1. Du, X. et al. (2000) Eur. Cytokine Netw. 11:362.
  2. Chuang, T.H. and R.J. Ulevitch (2000) Eur. Cytokine Netw. 11:372.
  3. Hornung, V. et al. (2002) J. Immunol. 168:4531.
  4. Melchjorsen, J. et al. (2005) J. Virol. 79:12944.
  5. Gantier, M.P. et al. (2008) J. Immunol. 180:2117.

Long Name

Toll-like Receptor 7

Alternate Names

toll-like receptor 7

Entrez Gene IDs

51284 (Human); 170743 (Mouse); 317468 (Rat)

Gene Symbol

TLR7

UniProt

Q9NYK1

Additional TLR7 Products

Product Documents for Recombinant Human TLR7 Fc Chimera Protein, CF

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Recombinant Human TLR7 Fc Chimera Protein, CF

For research use only

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