Recombinant Human Transglutaminase 7/TGM7 Protein, CF
R&D Systems, part of Bio-Techne | Catalog # 5426-TG
Key Product Details
Product Specifications
Source
Spodoptera frugiperda, Sf 21 (baculovirus)-derived human Transglutaminase 7/TGM7 protein
Asp2-Pro710, with an N-terminal Met and 6-His tag
Accession # Q96PF1
Asp2-Pro710, with an N-terminal Met and 6-His tag
Accession # Q96PF1
Purity
>90%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Endotoxin Level
<1.0 EU per 1 μg of the protein by the LAL method.
N-terminal Sequence Analysis
No result obtained
Predicted Molecular Mass
81 kDa
SDS-PAGE
75-78 kDa
Activity
Measured by its ability to form CBZ-Gln-Gly-Hydroxamate from CBZ-Gln-Gly and Hydroxylamine.
The specific activity is >350 pmol/min/μg, as measured under the described conditions.
The specific activity is >350 pmol/min/μg, as measured under the described conditions.
Formulation, Preparation and Storage
5426-TG
| Formulation | Supplied as a 0.2 μm filtered solution in Tris, NaCl and Glycerol. |
| Shipping | The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below. |
| Stability & Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
|
Background: Transglutaminase 7/TGM7
Transglutaminase 7 (TG7), encoded by the TGM7 gene, is also known as protein-glutamine-g-glutamyltransferase Z (Tgase Z) (1). It belongs to the family of Transglutaminases that catalyze the posttranslational modification of proteins via calcium dependent cross-linking reactions (2-4). TG7 is ubiquitously expressed in humans (1). Members of the TGM family have been implicated in a variety of human diseases including neurodegenerative diseases, celiac disease, lamellar ichthyosis, bleeding disorders, cataract formation, atherosclerosis, and others (5).
References
- Grenard, P. et al. (2001) J. Biol. Chem. 276:33066.
- Gentile, V. et al. (1991) J. Biol. Chem. 266:478.
- Chen, J.S.K. and Mehta K. (1999) Internat. J. Biochem. Cell Biol. 31:817.
- Griffin, M. et al. (2002) Biochem. J. 368:377.
- Kim, S-Y. et al. (2002) Neurochem. Int. 40:85.
Alternate Names
TGM7, TGMZ, TGZ
Gene Symbol
TGM7
UniProt
Additional Transglutaminase 7/TGM7 Products
Product Documents for Recombinant Human Transglutaminase 7/TGM7 Protein, CF
Product Specific Notices for Recombinant Human Transglutaminase 7/TGM7 Protein, CF
For research use only
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