Recombinant Mouse CD39L1/ENTPD2 Protein, CF
R&D Systems, part of Bio-Techne | Catalog # 5797-EN
Key Product Details
Product Specifications
Source
Chinese Hamster Ovary cell line, CHO-derived mouse CD39L1/ENTPD2 protein
Cys26-Ser462, with a C-terminal 6-His tag
Cys26-Ser462, with a C-terminal 6-His tag
Purity
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Endotoxin Level
<1.0 EU per 1 μg of the protein by the LAL method.
N-terminal Sequence Analysis
Cys26
Predicted Molecular Mass
49 kDa
SDS-PAGE
60-80 kDa, reducing conditions
Activity
Measured by its ability to hydrolyze the 5’-phosphate groups from the substrate adenosine-5’-triphosphate (ATP). The orthophosphate product is measured by a Malachite Green Phosphate Detection Kit (Catalog # DY996).
The specific activity is >9,000 pmol/min/μg, as measured under the described conditions.
The specific activity is >9,000 pmol/min/μg, as measured under the described conditions.
Formulation, Preparation and Storage
5797-EN
| Formulation | Supplied as a 0.2 μm filtered solution in Tris, NaCl, CaCl2 and Glycerol. |
| Shipping | The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below. |
| Stability & Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
|
Background: CD39L1/ENTPD2
CD39L1, also known as ENTPD2 and NTPDase2, is an ecto-nucleotidase belonging to the CD39 family. It is found on the surface of vascular adventitial cells and accessory vascular cells (1). CD39L1 is a Ca2+- and Mg2+-dependent enzyme that activates platelets by preferentially converting ATP to ADP (2). CD39L1 plays a role in regulating thrombosis and inflammation (3). It is considered to be a therapeutic target for thromboregulation and the treatment of vascular inflammation (2, 4).
References
- Zimmermann, H. et al. 2000 Proceedings of the Second International Workshop on Ecto-ATPases and Related Ectonucleotidases:18.
Robson ,S.C. et al.- Marcus, A.J. et al. 2005 Semin. Thromb. Hemost. 31:234.
- Sevigny, J. et al. 2002 Blood 99:2801.
Long Name
Ecto-Nucleoside Triphosphate Diphosphohydrolase 2
Alternate Names
CD39L1, Ecto-ATPase, ENTPD2, NTPD2, NTPDase 2
Gene Symbol
ENTPD2
UniProt
Additional CD39L1/ENTPD2 Products
Product Documents for Recombinant Mouse CD39L1/ENTPD2 Protein, CF
Product Specific Notices for Recombinant Mouse CD39L1/ENTPD2 Protein, CF
For research use only
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