Recombinant Rat CSMD1 Protein, CF

R&D Systems, part of Bio-Techne | Catalog # 9714-CS

R&D Systems, part of Bio-Techne
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9714-CS-050
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Key Product Details

Source

NS0

Accession #

NP_001032404

Conjugate

Unconjugated

View all CSMD1 Proteins and Enzymes »

Product Specifications

Source

Mouse myeloma cell line, NS0-derived rat CSMD1 protein
Ala2081-Ser3170, with a C-terminal 6-His tag

Purity

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

Endotoxin Level

<0.10 EU per 1 μg of the protein by the LAL method.

N-terminal Sequence Analysis

No results obtained. Ala2081 predicted

Predicted Molecular Mass

119 kDa

SDS-PAGE

138-173 kDa, reducing conditions

Activity

Bioassay data are not available.

Formulation, Preparation and Storage

9714-CS
Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution
Reconstitute at 500 μg/mL in PBS.

Reconstitution Buffer Available:
Size / Price
Qty
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: CSMD1

Cub and sushi multiple domains-1 (CSMD1), also known as multiple domain complement regulator 1, is an approximately 388-kDa member of the neuronal cub and sushi multiple domains family that plays a role in the regulation of inflammation and complement activation (1). It may also act as a tumor suppressor and be involved in growth cone functions such as amoeboid motility and cell-cell interaction (2, 3). This 3535 amino acid (aa) transmembrane protein is highly expressed in the central nervous system and epithelial tissues. The rat CSMD1 extracellular domain (ECD) consists of 14 N-terminal cub domains that alternate with sushi domains, followed by 15 C-terminal sushi domains (1). Within the ECD, rat CSMD1 shares 93% and 98% sequence identity with human and mouse CSMD1, respectively.

References

  1. Kraus, D. et al. (2006) J. Immunol. 176:4419.
  2. Ma, C. et al. (2009) Cancer Biol. Ther. 8:907.
  3. Kamal, M. et al. (2010) Breast Cancer Res. Treat. 121:555.

Long Name

CUB And Sushi Multiple Domains 1

Alternate Names

CSMD-1, KIAA1890, Mdcr1, PPP1R24

Entrez Gene IDs

64478 (Human); 94109 (Mouse); 364634 (Rat)

Gene Symbol

CSMD1

UniProt

NP_001032404

Additional CSMD1 Products

Product Documents for Recombinant Rat CSMD1 Protein, CF

Product Datasheets

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Product Specific Notices for Recombinant Rat CSMD1 Protein, CF

For research use only

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