Recombinant Rhesus Macaque/Cynomolgus IFN-alpha Protein

R&D Systems, part of Bio-Techne | Catalog # 14110-1

R&D Systems, part of Bio-Techne
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Key Product Details

Source

E. coli

Accession #

XM_001107516

Conjugate

Unconjugated

Applications

Bioactivity

View all IFN-alpha Proteins and Enzymes »

Product Specifications

Source

E. coli-derived cynomolgus monkey IFN-alpha protein

Purity

>98%, by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie® Blue stain.

Endotoxin Level

<1.0 EU per 1 μg of the protein by the LAL method.

Predicted Molecular Mass

19.5 kDa

Activity

Interferon was titrated with the use of the cytopathic effect inhibition assay as listed. The protein has similar activity to Human IFN Alpha 2 on human, rhesus and bovine cells.

Bovine (MDBK/VSV) – performed as described [Rubinstein et al. (1981) J. Virol. 37(2):755] The EC50 for interferon in this assay is ~5 U/ml.

Human (A549/EMCV) – performed as described [Budd et al. (1985) Canc. Chem. Pharm. 12:39]. The EC50 for interferon in this assay is ~1 U/ml.

 

Formulation, Preparation and Storage

14110-1
Formulation Phosphate buffered saline (PBS) containing 0.1% bovine serum albumin (BSA)
Shipping The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Background: IFN-alpha

Interferon-alpha (IFN-alpha), also known as leukocyte interferon, represents a group of related but distinct proteins that share over 95% amino acid sequence homology. They are members of the type I interferon family which share a common cell surface receptor composed of two subunits, a 100 kDa ligand-binding subunit (IFN-alpha R2) and a 125 kDa ligand binding and signal transduction subunit (IFN-alpha R1) that is involved both in ligand binding and signal transduction. IFN-alpha has both anti-viral and immunomodulatory activities on target cells.

Long Name

Interferon alpha

Alternate Names

IFNalpha, LeIF D

Entrez Gene IDs

3440 (Human)

Gene Symbol

IFNA2

UniProt

XM_001107516

Additional IFN-alpha Products

Product Documents for Recombinant Rhesus Macaque/Cynomolgus IFN-alpha Protein

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Recombinant Rhesus Macaque/Cynomolgus IFN-alpha Protein

For research use only

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