Recombinant Human Sentan His Protein

Name: Recombinant Human Sentan His Protein
Brand: Novus Biologicals
SKU: NBP1-78804

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-78804

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Technical Data
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Product Specifications
Scientific Data
Preparation & Storage
Background
Product Documents
Specific Notices

Key Product Details

Source

E. coli

Tag

His

Conjugate

Unconjugated

Applications

SDS-PAGE

View all Sentan Proteins and Enzymes »

Product Specifications

Description

A recombinant protein with a N-Terminal His-tag and corresponding to the amino acids 1-147 of Human Sentan

Source: E.coli

Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MGGCMHSTQD KSLHLEGDPN PSAAPTSTCA PRKMPKRISI SKQLASVKAL RKCSDLEKAI ATTALIFRNS SDSDGKLEKA IAKDLLQTQF RNFAEGQETK PKYREILSEL DEHTENKLDF EDFMILLLSI TVMSDLLQNI RNVKIMK

Purity

>90%, by SDS-PAGE

Predicted Molecular Mass

18.6 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Protein / Peptide Type

Recombinant Protein

Scientific Data Images for Recombinant Human Sentan His Protein

SDS-PAGE: Recombinant Human Sentan His Protein [NBP1-78804]

SDS-Page: Recombinant Human Sentan Protein [NBP1-78804] - 15% SDS-PAGE (3ug)

Formulation, Preparation and Storage

NBP1-78804

Formulation	20 mM Tris-HCl buffer (pH8.0), 50% glycerol, 0.15 M NaCl, 1 mM DTT
Preservative	No Preservative
Concentration	0.5 mg/ml
Shipping	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage	Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Sentan

SNTN, also known as sentan, belongs to the S-100 family. SNTN is shown to localize exclusively to the bridging structure between the cell membrane and peripheral singlet microtubules, which specifically exists in the narrowed distal portion of cilia. Exogenously expressed sentan showed affinity for the membrane protrusions, and a protein-lipid binding assay revealed that sentan bound to phosphatidylserine. These findings suggest that sentan is the first molecular component of the ciliary tip to bridge the cell membrane and peripheral singlet microtubules, making the distal portion of the cilia narrow and stiff to allow for better airway clearance or ovum transport. Recombinant human SNTN protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.

Alternate Names

FLJ44379, S100A1L, sentan, sentan, cilia apical structure protein

Gene Symbol

SNTN

Additional Sentan Products

Product Documents for Recombinant Human Sentan His Protein

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COA

Product Specific Notices for Recombinant Human Sentan His Protein

This product is for research use only and is not approved for use in humans or in clinical diagnosis. This product is guaranteed for 1 year from date of receipt.

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