Recombinant Human Serpin A1/alpha 1-Antitrypsin Protein

Name: Recombinant Human Serpin A1/alpha 1-Antitrypsin Protein
Brand: Novus Biologicals
SKU: NBC1-18549

Novus Biologicals, part of Bio-Techne | Catalog # NBC1-18549

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Product Specifications
Scientific Data
Preparation & Storage
Background
Product Documents
Specific Notices

Key Product Details

Source

E. coli

Conjugate

Unconjugated

Applications

SDS-PAGE

View all Serpin A1/alpha 1-Antitrypsin Proteins and Enzymes »

Product Specifications

Description

An un-tagged recombinant protein corresponding to the amino acids 25-418 of Human Serpin A1/alpha 1-Antitrypsin

Source: E.coli

Amino Acid Sequence: MEDPQGDAAQ KTDTSHHDQD HPTFNKITPN LAEFAFSLYR QLAHQSNSTN IFFSPVSIAT AFAMLSLGTK ADTHDEILEG LNFNLTEIPE AQIHEGFQEL LRTLNQPDSQ LQLTTGNGLF LSEGLKLVDK FLEDVKKLYH SEAFTVNFGD TEEAKKQIND YVEKGTQGKI VDLVKELDRD TVFALVNYIF FKGKWERPFE VKDTEEEDFH VDQVTTVKVP MMKRLGMFNI QHCKKLSSWV LLMKYLGNAT AIFFLPDEGK LQHLENELTH DIITKFLENE DRRSASLHLP KLSITGTYDL KSVLGQLGIT KVFSNGADLS GVTEEAPLKL SKAVHKAVLT IDEKGTEAAG AMFLEAIPMS IPPEVKFNKP FVFLMIDQNT KSPLFMGKVV NPTQK

Purity

>90%, by SDS-PAGE

Predicted Molecular Mass

44.4 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Protein / Peptide Type

Recombinant Protein

Scientific Data Images for Recombinant Human Serpin A1/alpha 1-Antitrypsin Protein

SDS-PAGE: Recombinant Human Serpin A1/alpha 1-Antitrypsin Protein [NBC1-18549]

SDS-Page: Recombinant Human Serpin A1/alpha 1-Antitrypsin Protein [NBC1-18549] - Antitrypsin, 44.4 kDa (395 aa), confirmed by MALDI-TOF with a purity of 90% by SDS - PAGE

Formulation, Preparation and Storage

NBC1-18549

Formulation	20 mM Tris-HCl buffer (pH 7.5), 10% glycerol, 1mM DTT, 2mM EDTA
Preservative	No Preservative
Concentration	1 mg/ml
Shipping	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage	Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Serpin A1/alpha 1-Antitrypsin

Alpha 1 proteinase inhibitor (Antitrypsin) has a characteristic secondary structure of beta sheets and alpha helices. That is a serum glycoprotein synthesized in the liver. It acts as an elastase inhibitor, primarily inhibiting neutrophil elastase, chymotrypsin, collagenase, leucocytic proteases, plasmin, and thrombin, which may be released during inflammatory reactions in the lung. Also Increase in Antitrypsin occurs as an acute phase response to tissue necrosis and inflammation. Serum level of Antitrypsin is elevated in rheumatoid arthritis, bacterial infections, vasculitis, and carcinomatosis. Recombinant Antitrypsin protein was expressed in E.coli and purified by using conventional chromatography techniques.

Alternate Names

A1AT, alpha 1-Antitrypsin, alpha 1-Proteinase Inhibitor

Gene Symbol

SERPINA1

Additional Serpin A1/alpha 1-Antitrypsin Products

Product Documents for Recombinant Human Serpin A1/alpha 1-Antitrypsin Protein

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COA

Product Specific Notices for Recombinant Human Serpin A1/alpha 1-Antitrypsin Protein

This product is for research use only and is not approved for use in humans or in clinical diagnosis. This product is guaranteed for 1 year from date of receipt.

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