SESN1 Antibody Blocking Peptide

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-44993PEP

Novus Biologicals, part of Bio-Techne
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NBP1-44993PEP
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Key Product Details

Source

Synthetic

Conjugate

Unconjugated

Applications

Antibody Competition

View all SESN1 Proteins and Enzymes »

Product Specifications

Description

Synthetic peptide taken within amino acid region 1-50 on human SESN1 protein.

Accession #: Q9Y6P5

Source: Synthetic

Purity

>85%, by HPLC

Application Notes

This peptide is useful as a blocking peptide for NBP1-44993. For further blocking peptide related protocol, click here.

Protein / Peptide Type

Antibody Blocking Peptide

Scientific Data Images for SESN1 Antibody Blocking Peptide

Western Blot: SESN1 Antibody Blocking Peptide [NBP1-44993PEP]

Western Blot: SESN1 Antibody Blocking Peptide [NBP1-44993PEP]

Western Blot: SESN1 Blocking Peptide [NBP1-44993PEP] - Western Blot of SESN1 Blocking Peptide with SESN1 Antibody in DiluObuffer.

Formulation, Preparation and Storage

NBP1-44993PEP
Formulation Sodium Bicarbonate buffer, pH 8.00 containing up to 10% DMSO
Concentration 2.5 mg/ml
Shipping The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Store at -20C. Avoid freeze-thaw cycles.

Background: SESN1

Sestrin 1(SESN1), located on rat chromosome 20q13, belongs to the sestrin family of proteins. These proteins are cystein sulfinyl reductases and they modulate peroxide signaling and antioxidant defense (1). This family of proteins is only present in multicellular organisms ranging from nematodes to mammals. These proteins selectively reduce or repair hyperoxidized forms of typical 2-Cys peroxiredoxins within eukaryotes (2). Peroxiredoxins are the enzymes that metabolize peroxides. Expression of these proteins is regulated by p53, a tumor suppressor protein (3). Sestrin 1 is implicated in the inhibition of cell growth. It has been reported that Sestrin 1 activates AMP-responsive protein kinase (AMPK) and targets it to phosphorylate TSC2, a tumor suppressor. Phosphorylation of TSC2 stimulates its GAP activity which inhibits the activity of mTOR, a positive regulator of cell growth, thus leading to inhibition of cell proliferation and growth (4). Inhibition of mRNAs from sestrin 1 and 3 genes has been shown to substantially increase intracellular ROS levels. This increase in ROS is linked to Ras-induced mutagenesis which is one of the most common events in cancer (5). Sestrin 1 was also identified as a candidate gene for heterotaxia in humans (6). Recent studies have identified that AMPK is an essential mediator of tumor suppressor LKB1 and is suppressed in cancer cells (7). Since activity of AMPK is regulated by sestrin 1, this protein could be a promising target for cancer treatment and therapy. Sestrin 1 is approximately a 66.1kDa protein in humans (551 amino acids) and 55.4kDa protein in mouse and rat (462 amino acids).

Alternate Names

MGC138241, MGC142129, p53-regulated protein PA26, PA26p53 activated gene 26, SEST1p53 regulated PA26 nuclear protein, sestrin 1, sestrin-1

Gene Symbol

SESN1

Additional SESN1 Products

Product Documents for SESN1 Antibody Blocking Peptide

Product Datasheets

Certificate of Analysis

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Product Specific Notices for SESN1 Antibody Blocking Peptide

This product is for research use only and is not approved for use in humans or in clinical diagnosis. This product is guaranteed for 1 year from date of receipt.

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