Recombinant Human SOD1/Cu-Zn SOD Active, Monomer Protein

Name: Recombinant Human SOD1/Cu-Zn SOD Active, Monomer Protein
Brand: Novus Biologicals
SKU: NBP3-14782

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-14782

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Product Specifications
Scientific Data
Preparation & Storage
Background
Product Documents
Specific Notices

Key Product Details

Conjugate

Unconjugated

Applications

Functional Assay, SDS-PAGE, Western Blot

View all SOD1/Cu-Zn SOD Proteins and Enzymes »

Product Specifications

Description

A full length recombinant protein of Human SOD1/Cu-Zn SOD

Source: E. coli

Uniprot ID: P00441

Purity

>95%, by SDS-PAGE

Localization

Nucleus, Mitochondrion, Cytoplasm

Protein / Peptide Type

Recombinant Protein

Scientific Data Images for Recombinant Human SOD1/Cu-Zn SOD Active, Monomer Protein

In vitro assay: Recombinant Human SOD1/Cu-Zn SOD Active, Monomer Protein [NBP3-14782]

In vitro assay: Recombinant Human SOD1/Cu-Zn SOD Active, Monomer Protein [NBP3-14782] - Thioflavin T assay of SOD1 pre-formed fibrils (PFFs) combined with SOD1 monomers (NBP3-14782). Pre-formed fibrils seed the aggregation of monomers, leading to an increase in Thioflavin T fluorescence

SDS-PAGE: Recombinant Human SOD1/Cu-Zn SOD Active, Monomer Protein [NBP3-14782]

SDS-Page: Recombinant Human SOD1/Cu-Zn SOD Active, Monomer Protein [NBP3-14782] - SDS-PAGE of human SOD1 monomer protein (NBP3-14782). Load: 2 ug

Formulation, Preparation and Storage

NBP3-14782

Preparation Method	Ion-exchange Purified
Formulation	PB pH 7.4
Preservative	No Preservative
Concentration	Please see the vial label for concentration. If unlisted please contact technical services.
Shipping	The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage	Store at -80C. Avoid freeze-thaw cycles.

Background: SOD1/Cu-Zn SOD

FUNCTION: Destroys radicals which are normally produced within the cells and which are toxic to biological systems. CATALYTIC ACTIVITY: 2 superoxide + 2 H+ = O2 + H2O2. COFACTOR: Binds 1 copper ion per subunit. COFACTOR: Binds 1 zinc ion per subunit. SUBUNIT: Homodimer. SUBCELLULAR LOCATION: Cytoplasm. DISEASE: Defects in SOD1 are the cause of familial amyotrophic lateral sclerosis (FALS); also called amyotrophic lateral sclerosis 1 (ALS1 or ALS). ALS is a degenerative disorder of motorneurons in the cortex, brainstem and spinal cord. ALS is characterized by muscular weakness and atrophy beginning in the hands and spreading to the forearms and legs. Muscle fasciculations are commonly visible. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. ALS is sometimes referred to as Lou Gehrig disease after the famous American baseball player who was diagnosed with the disorder. FALS, the familial form of ALS, accounts for about 10% of the cases and is transmitted in an autosomal dominant manner. The mean age at onset of FALS is 45 years. MISCELLANEOUS: Zinc binding promotes dimerization. SIMILARITY: Belongs to the Cu-Zn superoxide dismutase family.

Long Name

Superoxide Dismutase-1

Alternate Names

Cu-Zn SOD, CuZn SOD, Ipo1, IPOA, SOD, cytosolic, SOD, Soluble

Gene Symbol

SOD1

Additional SOD1/Cu-Zn SOD Products

Product Documents for Recombinant Human SOD1/Cu-Zn SOD Active, Monomer Protein

Product Datasheets

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COA

Product Specific Notices for Recombinant Human SOD1/Cu-Zn SOD Active, Monomer Protein

Please note that the 200ug and 500ug sizes are sent in 2x100ug and 5x100ug vials, respectively

This product is for research use only and is not approved for use in humans or in clinical diagnosis. This product is guaranteed for 1 year from date of receipt.

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