Recombinant Rat SOD2/Mn-SOD His Protein

Name: Recombinant Rat SOD2/Mn-SOD His Protein
Brand: Novus Biologicals
SKU: NBP3-18329

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-18329

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Product Specifications
Scientific Data
Preparation & Storage
Background
Product Documents
Specific Notices

Key Product Details

Tag

His

Conjugate

Unconjugated

Applications

SDS-PAGE, Western Blot

View all SOD2/Mn-SOD Proteins and Enzymes »

Product Specifications

Description

A partial recombinant protein corresponding to rat SOD2/Mn-SOD.

Source: E. coli

Purity

>85%

Predicted Molecular Mass

25 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Localization

Mitochondrion Matrix

Protein / Peptide Type

Partial Recombinant Protein

Scientific Data Images for Recombinant Rat SOD2/Mn-SOD His Protein

SDS-PAGE: Recombinant Rat SOD2/Mn-SOD His Protein [NBP3-18329]

SDS-Page: Recombinant Rat SOD2/Mn-SOD His Protein [NBP3-18329] - SDS-PAGE of 25kDa rat SOD2/Mn-SOD (NBP3-18329).

Formulation, Preparation and Storage

NBP3-18329

Preparation Method	This protein is affinity purified.
Formulation	50mM Tris/HCl pH7.7, 0.3M NaCl
Preservative	No Preservative
Concentration	Please see the vial label for concentration. If unlisted please contact technical services.
Shipping	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage	Store at -20C. Avoid freeze-thaw cycles.

Background: SOD2/Mn-SOD

Superoxide dismutase (SOD) is responsible for the elimination of cytotoxic active oxygen by catalyzing the dismutation of the superoxide radical to oxygen and hydrogen peroxide (1, 2, 3). There are three SOD isoenzymes in mammalian cells. They are: extracellular SOD (EC SOD), copper and zinc-containing SOD (CuZn SOD) and manganese-containing SOD (Mn SOD, SOD-2). The CuZn form contains Cu and Zn ions and exists as a 32 kDa dimer in the cytosol. Mn SOD is an 80 kDa tetramer that contains Mn ion and resides in the mitochondrial matrix. Mn SOD is a tumor necrosis factor (TNF)-inducible enzyme that protects cells from NFmediated apoptosis (4) via superoxide anion detoxification and the subsequent regulation of apoptosis through cytochrome c release and the modulation of the redox state of the mitochondria (6). Mn SOD has also been shown to be a tumor suppressor in human breast cancer (7). Overexpression of this enzyme protects neurons from NMDAand nitric oxide-induced neurotoxicity.

Long Name

Superoxide Dismutase-2

Alternate Names

IPO-B, Mn SOD, MnSOD, SOD, Mitochodrial

Gene Symbol

SOD2

Additional SOD2/Mn-SOD Products

Product Documents for Recombinant Rat SOD2/Mn-SOD His Protein

Product Datasheets

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COA

Product Specific Notices for Recombinant Rat SOD2/Mn-SOD His Protein

This product is for research use only and is not approved for use in humans or in clinical diagnosis. This product is guaranteed for 1 year from date of receipt.

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