Recombinant Mouse TRANCE/TNFSF11/RANK L Protein

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-77509

Novus Biologicals, part of Bio-Techne
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Key Product Details

Source

E. coli

Conjugate

Unconjugated

Applications

SDS-PAGE

View all TRANCE/TNFSF11/RANK L Proteins and Enzymes »

Product Specifications

Description

A recombinant protein with a un-tagged and corresponding to the amino acids 158-316 of Mouse TRANCE/RANK L/TNFSF11.

Source: E.coli

Amino Acid Sequence: MKPEAQPFAH LTINAASIPS GSHKVTLSSW YHDRGWAKIS NMTLSNGKLR VNQDGFYYLY ANICFRHHET SGSVPTDYLQ LMVYVVKTSI KIPSSHNLMK GGSTKNWSGN SEFHFYSINV GGFFKLRAGE EISIQVSNPS LLDPDQDATY FGAFKVQDID

Purity

>90%, by SDS-PAGE

Endotoxin Level

< 1.0 EU per 1ug of protein (determined by LAL method)

Predicted Molecular Mass

17.9 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Protein / Peptide Type

Recombinant Protein

Scientific Data Images for Recombinant Mouse TRANCE/TNFSF11/RANK L Protein

SDS-PAGE: Recombinant Mouse TRANCE/TNFSF11/RANK L Protein [NBP2-77509]

SDS-PAGE: Recombinant Mouse TRANCE/TNFSF11/RANK L Protein [NBP2-77509]

SDS-Page: Recombinant Mouse TRANCE/TNFSF11/RANK L Protein [NBP2-77509] - 3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain. Molecular Weight: 17.9 kDa (160aa) confirmed by MALDI-TOF.

Formulation, Preparation and Storage

NBP2-77509
Formulation 20mM Tris-HCl buffer (pH8.5), 0.1M NaCl
Preservative No Preservative
Concentration 1 mg/ml
Shipping The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: TRANCE/TNFSF11/RANK L

TRANCE/OPGL/RANKL/ODF is a recently identified member of tumor necrosis factor family. TRANCE (TNF-related activation-induced cytokine receptor) or RANKL {receptor activator of NF-kB (RANK) ligand} has been implicated in interactions between T cells and dendritic cells (1-2). RANK ligand (RANKL/TRANCE) binds to RANK on dendritic cells, upregulates the expression of anti-apoptotic protein BcL-XL suggesting a role in dendritic cell survival (2). TRANCE/RANKL is also important in T and B-cell maturation (3). As OPGL/ODF (Osteoprotegerin Ligand/Osteoclast differentiation factor), the same protein can both activate mature osteoclasts and mediate osteoclastogenesis (4). OPGL/TRANCE deficient mice show severe osteoporesis and complete absence of osteoclasts as a result of lack of osteogenesis (3).

Long Name

TNF-related Activation-induced Cytokine

Alternate Names

CD254, ODF, OPGL, RANK L, RANKL, TNFSF11

Gene Symbol

TNFSF11

Additional TRANCE/TNFSF11/RANK L Products

Product Documents for Recombinant Mouse TRANCE/TNFSF11/RANK L Protein

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Recombinant Mouse TRANCE/TNFSF11/RANK L Protein

This product is for research use only and is not approved for use in humans or in clinical diagnosis. This product is guaranteed for 1 year from date of receipt.

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