1-Naphthyl PP1

Name: 1-Naphthyl PP1
Brand: Tocris Bioscience
SKU: 3063

Tocris Bioscience, part of Bio-Techne | Catalog # 3063

Citations (15)

COA / SDS

Src family kinase inhibitor; also inhibits c-Abl

Key Product Details

Description:	Src family kinase inhibitor; also inhibits c-Abl
Alternative Names:	1-NA-PP 1
Chemical Name:	1-(1,1-Dimethylethyl)-3-(1-naphthalenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Purity:	≥99% (HPLC)
Molecular Weight:	317.39

View Full Technical Details for 1-Naphthyl PP1

Technical Data
Citations

Biological Activity for 1-Naphthyl PP1

1-Naphthyl PP1 is a selective inhibitor of src family kinases v-Src and c-Fyn as well as the tyrosine kinase c-Abl. (IC₅₀ values are 1.0, 0.6, 0.6, 18 and 22 μM for v-Src, c-Fyn, c-Abl, CDK2 and CAMK II respectively). Preferentially inhibits mutant over wild-type kinases (IC₅₀ values are 1.5 vs 1000 nM for I338G v-src and v-src respectively).

Compound Libraries for 1-Naphthyl PP1

1-Naphthyl PP1 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for 1-Naphthyl PP1

M. Wt	317.39
Formula	C₁₉H₁₉N₅
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	221243-82-9
PubChem ID	4877
InChi Key	XSHQBIXMLULFEV-UHFFFAOYSA-N
Smiles	NC1=NC=NC2=C1C(C3=C4C(C=CC=C4)=CC=C3)=NN2C(C)(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 1-Naphthyl PP1

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	6.35	20

Preparing Stock Solutions for 1-Naphthyl PP1

The following data is based on the product molecular weight 317.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	15.75 mL	78.77 mL	157.53 mL
1 mM	3.15 mL	15.75 mL	31.51 mL
2 mM	1.58 mL	7.88 mL	15.75 mL
10 mM	0.32 mL	1.58 mL	3.15 mL

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References for 1-Naphthyl PP1

References are publications that support the biological activity of the product.

Bishop Generation of monospecific nanomolar tyrosine kinase inhibitors via a chemical genetic approach. J.Am.Chem.Soc.
Bishop A chemical switch for inhibitor-sensitive alleles of any protein kinase. Nature 2000 PMID: 11014197