1S,3R-RSL3

Name: 1S,3R-RSL3
Brand: Tocris Bioscience
SKU: 6118

Tocris Bioscience, part of Bio-Techne | Catalog # 6118

Citations (8)

COA / SDS

Inhibits glutathione peroxidase (GPX4); induces ferroptosis

Key Product Details

Description:	Inhibits glutathione peroxidase (GPX4); induces ferroptosis
Chemical Name:	(1S,3R)-Methyl 2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1-[4-(methoxycarbonyl)phenyl]-1H-pyrido[3,4-b]indole-3-carboxylate
Purity:	≥98% (HPLC)
Molecular Weight:	440.88

View Full Technical Details for 1S,3R-RSL3

Technical Data
Citations

Biological Activity for 1S,3R-RSL3

1S,3R-RSL3 is a glutathione peroxidase 4 (GPX4) inhibitor. Induces ferroptosis. Increases lipid peroxidase levels in vitro. Inhibits tumor formation and progression in vivo.

Negative control 1R,3R-RSL3 (Cat. No. 6687) also available.

Licensing Information

Sold with the permission of Columbia University.

Technical Data for 1S,3R-RSL3

M. Wt	440.88
Formula	C₂₃H₂₁ClN₂O₅
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1219810-16-8
PubChem ID	16398939
InChi Key	TXJZRSRTYPUYRW-YMXDCFFPSA-N
Smiles	COC([C@H]1CC2=C([C@H](C3=CC=C(C(OC)=O)C=C3)N1C(CCl)=O)NC4=CC=CC=C24)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 1S,3R-RSL3

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	44.09	100

Preparing Stock Solutions for 1S,3R-RSL3

The following data is based on the product molecular weight 440.88.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.27 mL	11.34 mL	22.68 mL
5 mM	0.45 mL	2.27 mL	4.54 mL
10 mM	0.23 mL	1.13 mL	2.27 mL
50 mM	0.05 mL	0.23 mL	0.45 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for 1S,3R-RSL3

References are publications that support the biological activity of the product.

Yang Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis. Proc.Natl.Acad.Sci.U.S.A. 2016 PMID: 27506793
Feng & Stockwell Unsolved mysteries: How does lipid peroxidation cause ferroptosis? PLoS. Biol. 2018 PMID: 29795546
Yang Regulation of ferroptotic cancer cell death by GPX4. Cell. 2014 PMID: 24439385