8-Bromo-cAMP, sodium salt

Name: 8-Bromo-cAMP, sodium salt
Brand: Tocris Bioscience
SKU: 1140
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1140

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Citations (46)

COA / SDS

Cell-permeable cAMP analog

Key Product Details

Description:	Cell-permeable cAMP analog
Chemical Name:	8-Bromoadenosine-3',5'-cyclic monophosphate sodium salt
Purity:	≥99% (HPLC)
Molecular Weight:	430.09

View Full Technical Details for 8-Bromo-cAMP, sodium salt

Technical Data
Citations / Reviews (1)

Biological Activity for 8-Bromo-cAMP, sodium salt

8-Bromo-cAMP, sodium salt is a cell-permeable cyclic AMP (cAMP) analog. It activates PKA and has greater resistance to hydrolysis by phosphodiesterase (PDE) than cAMP. It increases differentiation and induces apoptosis in an esophageal cancer cell line. 8-Bromo-cAMP enhances the induction of pluripotency in human fibroblast cells in combination with VPA (valproic acid) (Cat. No. 2815). In combination with IBMX (Cat. No. 2845), it promotes the differentiation of human iPS cell-derived intestinal epithelial cells. It induces cell-based VEGF production for angiogenesis and osteoblastic differentiation in vitro.

Compound Libraries for 8-Bromo-cAMP, sodium salt

8-Bromo-cAMP, sodium salt is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Epigenetics Library and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for 8-Bromo-cAMP, sodium salt

M. Wt	430.09
Formula	C₁₀H₁₀BrN₅NaO₆P
Storage	Store at -20°C
Purity	≥99% (HPLC)
CAS Number	76939-46-3
PubChem ID	23702958
InChi Key	DMRMZQATXPQOTP-GWTDSMLYSA-M
Smiles	[Na+].[H][C@@]12COP([O-])(=O)O[C@@]1([H])[C@@H](O)[C@@H](O2)N1C(Br)=NC2=C1N=CN=C2N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 8-Bromo-cAMP, sodium salt

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	43.01	100
	DMSO	43.01	100

Preparing Stock Solutions for 8-Bromo-cAMP, sodium salt

The following data is based on the product molecular weight 430.09.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.33 mL	11.63 mL	23.25 mL
5 mM	0.47 mL	2.33 mL	4.65 mL
10 mM	0.23 mL	1.16 mL	2.33 mL
50 mM	0.05 mL	0.23 mL	0.47 mL

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References for 8-Bromo-cAMP, sodium salt

References are publications that support the biological activity of the product.

Lo One-day treatment of small molecule 8-bromo-cyclic AMP analogue induces cell-based VEGF production for in vitro angiogenesis and osteoblastic differentiation. J.Tissue.Eng.Regen. Med. 2016 PMID: 24493289
Wang Dual effects of 8-Br-cAMP on differentiation and apoptosis of human esophageal cancer cell line Eca-109. World J.Gastroenterol. 2005 PMID: 16425431
Wang A cyclic AMP analog, 8-Br-cAMP, enhances the induction of pluripotency in human fibroblast cells. Stem Cell Rev. 2011 PMID: 21120637
Hei Lack of correlation between activation of cyclic AMP-dependent protein kinase and inhibition of contraction of rat vas deferens by cyclic AMP analogs. Mol.Pharmacol. 1991 PMID: 1847496
Chow Functional modulation of P2X₂ receptors by cyclic AMP-dependent protein kinase. J.Neurochem. 1998 PMID: 9603227
Carranza Protein kinase A induces recruitment of active Na⁺,K⁺-ATPase units to the plasma membrane of rat proximal convoluted tubule cells. J.Physiol. 1998 PMID: 9679177