A 410099.1 amide-PEG4-amine

Name: A 410099.1 amide-PEG4-amine
Brand: Tocris Bioscience
SKU: 7220

Tocris Bioscience, part of Bio-Techne | Catalog # 7220

COA / SDS

IAP ligand with PEG linker and terminal amine for onward chemistry

Key Product Details

Description:	IAP ligand with PEG linker and terminal amine for onward chemistry
Chemical Name:	tert-Butyl ((S)-1-(((S)-2-((2S,4S)-4-(14-amino-3,6,9,12-tetraoxatetradecanamido)-2-(((R)-1,2,3,4-tetrahydronaphthalen-1-yl)carbamoyl)pyrrolidin-1-yl)-1-cyclohexyl-2-oxoethyl)amino)-1-oxopropan-2-yl)(methyl)carbamate
Purity:	≥95% (HPLC)
Molecular Weight:	817.02

View Full Technical Details for A 410099.1 amide-PEG4-amine

Technical Data
Citations

Biological Activity for A 410099.1 amide-PEG4-amine

A 410099.1 amide-PEG4-amine is a functionalized IAP ligand for PROTAC^® research and development; incorporates an IAP ligand plus an amide-PEG4 linker with terminal amine ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Technical Data for A 410099.1 amide-PEG4-amine

M. Wt	817.02
Formula	C₄₂H₆₈N₆O₁₀
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	2446474-10-6
InChi Key	CDDABGWUXFFTGQ-MLSLTINKSA-N
Smiles	CN([C@H](C(N[C@H](C(N1C[C@@H](NC(COCCOCCOCCOCCN)=O)C[C@H]1C(N[C@@H]2CCCC3=CC=CC=C23)=O)=O)C4CCCCC4)=O)C)C(OC(C)(C)C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for A 410099.1 amide-PEG4-amine

References are publications that support the biological activity of the product.

Tinworth PROTAC-mediated degradation of Bruton's tyrosine kinase is inhibited by covalent binding. ACS Biol.Chem. 2019 PMID: 30807093