α-Estradiol

Name: α-Estradiol
Brand: Tocris Bioscience
SKU: 2823

Tocris Bioscience, part of Bio-Techne | Catalog # 2823

Citations (1)

COA / SDS

Endogenous estrogen receptor agonist

Key Product Details

Description:	Endogenous estrogen receptor agonist
Chemical Name:	(17α)-Estra-1,3,5(10)-triene-3,17-diol
Purity:	≥97% (HPLC)
Molecular Weight:	272.38

View Full Technical Details for α-Estradiol

Technical Data
Citations

Biological Activity for α-Estradiol

α-Estradiol is an endogenous estrogen receptor ligand (K_i values are 0.2 and 1.2 nM for ERα and ERβ receptors respectively).

β-Estradiol also available.

Technical Data for α-Estradiol

M. Wt	272.38
Formula	C₁₈H₂₄O₂
Storage	Store at RT
Purity	≥97% (HPLC)
CAS Number	57-91-0
PubChem ID	68570
InChi Key	VOXZDWNPVJITMN-SFFUCWETSA-N
Smiles	[H][C@@]23CCC1=CC(O)=CC=C1[C@]([H])2CC[C@@]4(C)[C@]([H])3CC[C@H]4O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for α-Estradiol

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	27.24	100
	ethanol	27.24	100

Preparing Stock Solutions for α-Estradiol

The following data is based on the product molecular weight 272.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.67 mL	18.36 mL	36.71 mL
5 mM	0.73 mL	3.67 mL	7.34 mL
10 mM	0.37 mL	1.84 mL	3.67 mL
50 mM	0.07 mL	0.37 mL	0.73 mL

Molarity Calculator

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Reconstitution Calculator

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References for α-Estradiol

References are publications that support the biological activity of the product.

Toran-Allerand ER-X: a novel, plasma membrane-associated, putative estrogen receptor that is regulated during development and after ischemic brain injury. J.Neurosci. 2002 PMID: 12351713
Kuiper Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors α and β. Endocrinology 1997 PMID: 9048584