β-Estradiol

Name: β-Estradiol
Brand: Tocris Bioscience
SKU: 2824

Tocris Bioscience, part of Bio-Techne | Catalog # 2824

Citations (18)

COA / SDS

Endogenous ER agonist

Key Product Details

Description:	Endogenous ER agonist
Alternative Names:	17 β-Estradiol
Chemical Name:	(17β)-Estra-1,3,5(10)-triene-3,17-diol
Purity:	≥99% (HPLC)
Molecular Weight:	272.38

View Full Technical Details for β-Estradiol

Technical Data
Citations

Biological Activity for β-Estradiol

β-Estradiol is an endogenous estrogen receptor (ER) agonist (K_i values are 0.12 and 0.13 nM for ERα and ERβ respectively). Also high affinity ligand at membrane estrogen GPR30 receptors.

α-Estradiol also available.

Technical Data for β-Estradiol

M. Wt	272.38
Formula	C₁₈H₂₄O₂
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	50-28-2
PubChem ID	5757
InChi Key	VOXZDWNPVJITMN-ZBRFXRBCSA-N
Smiles	[H][C@@]23CCC1=CC(O)=CC=C1[C@]([H])2CC[C@@]4(C)[C@]([H])3CC[C@@H]4O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for β-Estradiol

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	27.24	100
	ethanol	20.43	75 with gentle warming

Preparing Stock Solutions for β-Estradiol

The following data is based on the product molecular weight 272.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.67 mL	18.36 mL	36.71 mL
5 mM	0.73 mL	3.67 mL	7.34 mL
10 mM	0.37 mL	1.84 mL	3.67 mL
50 mM	0.07 mL	0.37 mL	0.73 mL

Molarity Calculator

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Reconstitution Calculator

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References for β-Estradiol

References are publications that support the biological activity of the product.

Thomas Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells. Endocrinology 2005 PMID: 15539556
Kuiper Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors α and β. Endocrinology 1997 PMID: 9048584

Product Documents for β-Estradiol

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.

SDS

⚠ WARNING: This product can expose you to chemicals including Estradiol 17B, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov