AMG 510

AMG 510 is a potent and selective covalent KRAS^G12C inhibitor (IC₅₀ = 90 nM). Also a potent inhibitor of phospho-ERK (IC₅₀ = 68 nM). In an in vivo model of non-small cell lung cancer, AMG 510 causes regression of tumors, an increase in T-cell recruitment and a pro-inflammatory tumor microenvironment. Synergises with MEK inhibitors and Carboplatin (Cat. No. 2626) and is orally bioavailable.