Amlexanox

Name: Amlexanox
Brand: Tocris Bioscience
SKU: 4857

Tocris Bioscience, part of Bio-Techne | Catalog # 4857

Citations (13)

COA / SDS

Selective inhibitor of TBK

Key Product Details

Description:	Selective inhibitor of TBK
Chemical Name:	2-Amino-7-(1-methylethyl)-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic acid
Purity:	≥99% (HPLC)
Molecular Weight:	298.29

View Full Technical Details for Amlexanox

Technical Data
Citations

Biological Activity for Amlexanox

Amlexanox is a selective inhibitor of TANK-binding kinase 1 (TBK1) and IKKε (IC₅₀ values are ~1-2 μM). Displays no effect on IKKα or IKKβ at these concentrations. Reversibly lowers weight, increases insulin sensitivity, and reduces inflammation and steatosis in three mouse models of obesity. Exhibits antiallergic activity; inhibits the release of histamine from rat mast cells. Also binds to Hsp90 and inhibits C-terminal chaperone activity in vitro.

Compound Libraries for Amlexanox

Amlexanox is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library, Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Amlexanox

M. Wt	298.29
Formula	C₁₆H₁₄N₂O₄
Storage	Store at -20°C
Purity	≥99% (HPLC)
CAS Number	68302-57-8
PubChem ID	2161
InChi Key	SGRYPYWGNKJSDL-UHFFFAOYSA-N
Smiles	CC(C)C1=CC=C2C(C(C(C=C(C(O)=O)C(N)=N3)=C3O2)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Amlexanox

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	29.83	100

Preparing Stock Solutions for Amlexanox

The following data is based on the product molecular weight 298.29.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.35 mL	16.76 mL	33.52 mL
5 mM	0.67 mL	3.35 mL	6.70 mL
10 mM	0.34 mL	1.68 mL	3.35 mL
50 mM	0.07 mL	0.34 mL	0.67 mL

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References for Amlexanox

References are publications that support the biological activity of the product.

Okada Hsp90 is a direct target of the anti-allergic drugs disodium cromoglycate and amle. Biochem.J. 2003 PMID: 12803546
Makino Mechanism of action of an antiallergic agent, amle. (AA-673), in inhibiting histamine release from mast cells. Acceleration of cAMP generation and inhibition of phosphodiesterase. Int.Arch.Allergy Appl.Immunol. 1987 PMID: 2433225
Reilly An inhibitor of the protein kinases TBK1 and IKK-ε improves obesity-related metabolic dysfunctions in mice. Nat.Med. 2012 PMID: 23396211