Amlexanox

Name: Amlexanox
Brand: Tocris Bioscience
SKU: 4857

Tocris Bioscience, part of Bio-Techne | Catalog # 4857

Citations (13)

COA / SDS

Selective inhibitor of TBK

Key Product Details

Chemical Name:	2-Amino-7-(1-methylethyl)-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic acid
Purity:	≥99%

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Technical Data
Citations

Biological Activity for Amlexanox

Amlexanox is a selective inhibitor of TANK-binding kinase 1 (TBK1) and IKKε (IC₅₀ values are ~1-2 μM). Displays no effect on IKKα or IKKβ at these concentrations. Reversibly lowers weight, increases insulin sensitivity, and reduces inflammation and steatosis in three mouse models of obesity. Exhibits antiallergic activity; inhibits the release of histamine from rat mast cells. Also binds to Hsp90 and inhibits C-terminal chaperone activity in vitro.

Technical Data for Amlexanox

Formula	C₁₆H₁₄N₂O₄
Storage	Store at -20°C
Purity	≥99%
CAS Number	68302-57-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Amlexanox

Solubility

Soluble Soluble to 100 mM in DMSO

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References for Amlexanox

References are publications that support the biological activity of the product.

Okada et al. Hsp90 is a direct target of the anti-allergic drugs disodium cromoglycate and amle. Biochem.J., 2003;374:433 PMID: 12803546
Makino et al. Mechanism of action of an antiallergic agent, amle. (AA-673), in inhibiting histamine release from mast cells. Acceleration of cAMP generation and inhibition of phosphodiesterase. Int.Arch.Allergy Appl.Immunol., 1987;82:66 PMID: 2433225
Reilly et al. An inhibitor of the protein kinases TBK1 and IKK-ε improves obesity-related metabolic dysfunctions in mice. Nat.Med., 2012;19:313 PMID: 23396211

Amlexanox

Tocris Bioscience, part of Bio-Techne | Catalog # 4857

Key Product Details

Biological Activity for Amlexanox

Technical Data for Amlexanox

Solubility for Amlexanox

Dilution Calculator

Reconstitution Calculator

References for Amlexanox

Product Documents for Amlexanox

COA

Certificate of Analysis

SDS

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