IkB Kinase Inhibitors: Small Molecules and Peptides
The classical active IKK complex, composed of IKK alpha, IKK beta, and two forms of processed IKK gamma, phosphorylates and inactivates IkB, resulting in the release and nuclear translocation of active NFkB. The regulatory IKK gamma is required for activation of the IKK complex. IKK epsilon is an IKK-related kinase with 30% structural homology to IKK alpha and beta, and is present in a subset of IKK complexes.
10 results for "IkB Kinase Inhibitors Small Molecules and Peptides" in Products
10 results for "IkB Kinase Inhibitors Small Molecules and Peptides" in Products
IkB Kinase Inhibitors: Small Molecules and Peptides
The classical active IKK complex, composed of IKK alpha, IKK beta, and two forms of processed IKK gamma, phosphorylates and inactivates IkB, resulting in the release and nuclear translocation of active NFkB. The regulatory IKK gamma is required for activation of the IKK complex. IKK epsilon is an IKK-related kinase with 30% structural homology to IKK alpha and beta, and is present in a subset of IKK complexes.
Potent, selective inhibitor of IKKβ
| Chemical Name: | 2-[(Aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide |
| Purity: | ≥97% |
Selective IKKα and IKKβ inhibitor
| Chemical Name: | 2-Amino-6-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-4-(4-piperidinyl)-3-pyridinecarbonitrile |
| Purity: | ≥97% |
Salt inducible kinase (SIK) inhibitor; also ULK1 and 2 inhibitor
| Chemical Name: | N-[3-[[5-Cyclopropyl-2-[[3-(4-morpholinylmethyl)phenyl]amino]-4-pyrimidinyl]amino]propyl]cyclobutanecarboxamide dihydrochloride |
| Purity: | ≥98% |
Selective inhibitor of TBK
| Chemical Name: | 2-Amino-7-(1-methylethyl)-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic acid |
| Purity: | ≥99% |
Selective inhibitor of IKK
| Chemical Name: | N-(4-Pyrrolidin-1-yl-piperidin-1-yl)-[4-(4-benzo[b]thiophen-2-yl-pyrimidin-2-ylamino)phenyl]carboxamide hydrochloride |
| Purity: | ≥98% (HPLC) |
Selective allosteric inhibitor of IKK; anti-inflammatory
| Chemical Name: | N1-(1,8-Dimethylimidazo[1,2-a]quinoxalin-4-yl)-1,2-ethanediamine hydrochloride |
| Purity: | ≥99% (HPLC) |
Potent and selective IKKβ inhibitor
| Chemical Name: | 8-[[[5-Chloro-2-[3,4-dimethyl-3,4-bis(hydroxymethyl)-1-pyrrolidinyl]-4-pyridinyl]carbonyl]amino]-1-(4-fluorophenyl)-4,5-dihydro-1H-benz[g]indazole-3-carboxamide |
| Purity: | ≥98% (HPLC) |
Novel IKK2-selective inhibitor
| Chemical Name: | N-(6-Chloro-7-methoxy-9H-pyrido[3,4-b]indol-8-yl)-2-methyl-3-pyridinecarboxamide dihydrochloride |
| Purity: | ≥98% |
Inhibitor of IKKβ; also exhibits antibacterial activity
| Chemical Name: | N-[3,5-Bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide |
| Purity: | ≥99% |
Potent and selective IKKε inhibitor
| Chemical Name: | 5-(5,6-Dimethoxy-1H-benzimidazol-1-yl)-3-[[2-(methylsulfonyl)phenyl]methoxy]-2-thiophenecarbonitrile |
| Purity: | ≥98% (HPLC) |
