AT 101

Name: AT 101
Brand: Tocris Bioscience
SKU: 3367

Tocris Bioscience, part of Bio-Techne | Catalog # 3367

Citations (10)

COA / SDS

Downregulates Bcl-2 and Mcl-1; pro-apoptotic

Key Product Details

Description:	Downregulates Bcl-2 and Mcl-1; pro-apoptotic
Chemical Name:	(-)-1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-5,5'-bis(1-methylethyl)-[2,2'-binaphthalene]-8,8'-dicarboxaldehyde
Purity:	≥98% (HPLC)
Molecular Weight:	518.56

View Full Technical Details for AT 101

Technical Data
Citations

Biological Activity for AT 101

AT 101 is a R-(-)-enantiomer of gossypol (Cat. No. 1964). Mimics the BH3 domains of Bcl-2, Bcl-XL and Mcl-1. Disrupts heterodimerization of Bcl-2 with proapoptotic family members. Induces apoptosis in vitro through activation of caspase-9; cytotoxic to multiple myeloma and drug-resistant cell lines. Delays onset of androgen-independent growth of VCaP prostate cancer xenografts in vivo.

Compound Libraries for AT 101

AT 101 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for AT 101

M. Wt	518.56
Formula	C₃₀H₃₀O₈
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	90141-22-3
PubChem ID	3503
InChi Key	QBKSWRVVCFFDOT-UHFFFAOYSA-N
Smiles	OC1=[C@]([C@]2=C(O)C(C(C=O)=C(O)C(O)=C3C(C)C)=C3C=C2C)C(C)=CC4=C1C(C=O)=C(O)C(O)=C4C(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AT 101

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	10.37	20

Preparing Stock Solutions for AT 101

The following data is based on the product molecular weight 518.56.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	9.64 mL	48.21 mL	96.42 mL
1 mM	1.93 mL	9.64 mL	19.28 mL
2 mM	0.96 mL	4.82 mL	9.64 mL
10 mM	0.19 mL	0.96 mL	1.93 mL

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References for AT 101

References are publications that support the biological activity of the product.

Kline R-(-)-gossypol (AT-101) activates programmed cell death in multiple myeloma cells. Exp.Hematol. 2008 PMID: 18346839
Loberg In vivo evaluation of AT-101 (R-(-)-gossypol acetic acid) in androgen-independent growth of VCaP prostate cancer cells in combination with surgical castration. Neoplasia 2007 PMID: 18084610
Balakrishnan AT-101 induces apoptosis in CLL B cells and overcomes stromal cell-mediated Mcl-1 induction and drug resistance. Blood 2009 PMID: 18836097