Gossypol

Name: Gossypol
Brand: Tocris Bioscience
SKU: 1964

Tocris Bioscience, part of Bio-Techne | Catalog # 1964

Citations (11)

COA / SDS

Proapoptotic; downregulates Bcl-2 and Bcl-XL

Key Product Details

Chemical Name:	1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-5,5'-bis(1-methylethyl)-[2,2'-binaphthalene]-8,8'-dicarboxaldehyde
Purity:	≥98%
Molecular Weight:	518.56 kDa

View Full Technical Details for Gossypol

Technical Data
Citations

Biological Activity for Gossypol

Gossypol is a lipophilic agent derived from cottonseed. Exhibits multiple biological effects including antifertility and anticancer activity. Proapoptotic; downregulates Bcl-2 and Bcl-XL.

R-enantiomer also available.

Technical Data for Gossypol

M. Wt	518.56 kDa
Formula	C₃₀H₃₀O₈
Storage	Store at -20°C
Purity	≥98%
CAS Number	303-45-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Gossypol

Solubility

Soluble Soluble to 25 mM in ethanol with gentle warming and to 25 mM in DMSO

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References for Gossypol

References are publications that support the biological activity of the product.

Coutinh Gossypol: a contraceptive for men. Contraception, 2002;65:259 PMID: 12020773
Zhang et al. Molecular mechanism of gossypol-induced cell growth inhibition and cell death of HT-29 human colon carcinoma cells. Biochem.Pharmacol., 2003;66:93 PMID: 12818369
Vander Jagt et al. Gosspyol: prototype of inhibitors targeted to dinucleotide folds. Curr.Med.Chem., 2000;7:479 PMID: 10702620