Gossypol

Name: Gossypol
Brand: Tocris Bioscience
SKU: 1964

Tocris Bioscience, part of Bio-Techne | Catalog # 1964

Citations (11)

COA / SDS

Proapoptotic; downregulates Bcl-2 and Bcl-XL

Key Product Details

Description:	Proapoptotic; downregulates Bcl-2 and Bcl-XL
Chemical Name:	1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-5,5'-bis(1-methylethyl)-[2,2'-binaphthalene]-8,8'-dicarboxaldehyde
Purity:	≥98% (HPLC)
Molecular Weight:	518.56

View Full Technical Details for Gossypol

Technical Data
Citations

Biological Activity for Gossypol

Gossypol is a lipophilic agent derived from cottonseed. Exhibits multiple biological effects including antifertility and anticancer activity. Proapoptotic; downregulates Bcl-2 and Bcl-XL.

R-enantiomer also available.

Technical Data for Gossypol

M. Wt	518.56
Formula	C₃₀H₃₀O₈
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	303-45-7
PubChem ID	3503
InChi Key	QBKSWRVVCFFDOT-UHFFFAOYSA-N
Smiles	CC(C)C1=C(O)C(O)=C(C=O)C2=C(O)C(=C(C)C=C12)C1=C(O)C2=C(C=O)C(O)=C(O)C(C(C)C)=C2C=C1C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Gossypol

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	12.96	25 with gentle warming
	DMSO	12.96	25

Preparing Stock Solutions for Gossypol

The following data is based on the product molecular weight 518.56.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	7.71 mL	38.57 mL	77.14 mL
1.25 mM	1.54 mL	7.71 mL	15.43 mL
2.5 mM	0.77 mL	3.86 mL	7.71 mL
12.5 mM	0.15 mL	0.77 mL	1.54 mL

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References for Gossypol

References are publications that support the biological activity of the product.

Vander Jagt Gosspyol: prototype of inhibitors targeted to dinucleotide folds. Curr.Med.Chem. 2000 PMID: 10702620
Zhang Molecular mechanism of gossypol-induced cell growth inhibition and cell death of HT-29 human colon carcinoma cells. Biochem.Pharmacol. 2003 PMID: 12818369
Coutinh Gossypol: a contraceptive for men. Contraception 2002 PMID: 12020773