Balicatib

Name: Balicatib
Brand: Tocris Bioscience
SKU: 5585

Tocris Bioscience, part of Bio-Techne | Catalog # 5585

Citations (1)

COA / SDS

Potent and selective cathepsin K inhibitor

Key Product Details

Description:	Potent and selective cathepsin K inhibitor
Chemical Name:	N-[1-(Cyanomethylcarbamoyl)cyclohexyl]-4-(4-propylpiperazin-1-yl)benzamide
Purity:	≥98% (HPLC)
Molecular Weight:	411.54

View Full Technical Details for Balicatib

Technical Data
Citations

Biological Activity for Balicatib

Balicatib is a potent and selective cathepsin K inhibitor (IC₅₀ values are 1.4, 56 and 480 nM for human, rat and mouse cathepsin K, respectively). Exhibits >300-fold selectivity for cathepsin K over cathepsins L, B and S. Long term supratherapeutic dosing increases tissue levels of cathepsins L and B in rats.

Compound Libraries for Balicatib

Balicatib is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for Balicatib

M. Wt	411.54
Formula	C₂₃H₃₃N₅O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	354813-19-7
PubChem ID	10201696
InChi Key	LLCRBOWRJOUJAE-UHFFFAOYSA-N
Smiles	O=C(NC1(CCCCC1)C(NCC#N)=O)C(C=C2)=CC=C2N3CCN(CCC)CC3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Balicatib

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	41.15	100

Preparing Stock Solutions for Balicatib

The following data is based on the product molecular weight 411.54.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.43 mL	12.15 mL	24.30 mL
5 mM	0.49 mL	2.43 mL	4.86 mL
10 mM	0.24 mL	1.21 mL	2.43 mL
50 mM	0.05 mL	0.24 mL	0.49 mL

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References for Balicatib

References are publications that support the biological activity of the product.

Desmarais Effect of cathepsin k inhibitor basicity on in vivo off-target activities. Mol.Pharmacol. 2008 PMID: 17940194