BAY 1816032

Name: BAY 1816032
Brand: Tocris Bioscience
SKU: 7549

Tocris Bioscience, part of Bio-Techne | Catalog # 7549

Citations (2)

COA / SDS

Potent and selective BUB1 kinase inhibitor

Key Product Details

Description:	Potent and selective BUB1 kinase inhibitor
Chemical Name:	2-[3,5-Difluoro-4-[[3-[5-methoxy-4-[(3-methoxy-4-pyridinyl)amino]-2-pyrimidinyl]-1H-indazol-1-yl]methyl]phenoxy]ethanol
Purity:	≥98% (HPLC)
Molecular Weight:	534.52

View Full Technical Details for BAY 1816032

Technical Data
Citations

Biological Activity for BAY 1816032

BAY 1816032 is a potent and selective inhibitor of BUB1 kinase, a mitotic checkpoint serine/threonine kinase (IC₅₀ = 6.1 nM). BAY 1816032 shows 17-fold selectivity over a panel of 403 other human kinases. In vivo, BAY 1816032 decreases tumor size in tumor xenograft models. BAY 181603 is orally bioavailable.

Compound Libraries for BAY 1816032

BAY 1816032 is also offered as part of the Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for BAY 1816032

M. Wt	534.52
Formula	C₂₇H₂₄F₂N₆O₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1891087-61-8
PubChem ID	118958833
InChi Key	QVOGVAVHOLLLAZ-UHFFFAOYSA-N
Smiles	COC1=CN=C(N=C1NC2=C(C=NC=C2)OC)C3=NN(C4=CC=CC=C43)CC5=C(C=C(C=C5F)OCCO)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BAY 1816032

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	26.73	50

Preparing Stock Solutions for BAY 1816032

The following data is based on the product molecular weight 534.52.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	3.74 mL	18.71 mL	37.42 mL
2.5 mM	0.75 mL	3.74 mL	7.48 mL
5 mM	0.37 mL	1.87 mL	3.74 mL
25 mM	0.07 mL	0.37 mL	0.75 mL

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References for BAY 1816032

References are publications that support the biological activity of the product.

Siemeister Inhibition of BUB1 kinase by BAY 1816032 sensitizes tumor cells toward taxanes, ATR, and PARP inhibitors in vitro and in vivo. Clin.Cancer Res. 2019 PMID: 30429199