BMS 345541

Name: BMS 345541
Brand: Tocris Bioscience
SKU: 4806
Rating: 5 (2 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4806

(2)

Citations (14)

COA / SDS

Selective allosteric inhibitor of IKK; anti-inflammatory

Key Product Details

Description:	Selective allosteric inhibitor of IKK; anti-inflammatory
Chemical Name:	N¹-(1,8-Dimethylimidazo[1,2-a]quinoxalin-4-yl)-1,2-ethanediamine hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	291.78

View Full Technical Details for BMS 345541

Technical Data
Citations / Reviews (2)

Biological Activity for BMS 345541

BMS 345541 is a selective allosteric inhibitor of IKK (IC₅₀ values are 0.3 and 4.0 μM for IKKβ and IKKα respectively). Exhibits no effect against a panel of 15 other kinases. Attenuates LPS-induced cytokine production in vitro and blocks NFκB dependent transcription in mice. Also suppresses joint destruction in a mouse model of arthritis.

Compound Libraries for BMS 345541

BMS 345541 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for BMS 345541

M. Wt	291.78
Formula	C₁₄H₁₇N₅.HCl
Storage	Store at -20°C
Purity	≥99% (HPLC)
CAS Number	547757-23-3
PubChem ID	9926054
InChi Key	MIDKPVLYXNLFGZ-UHFFFAOYSA-N
Smiles	NCCNC1=NC3=C(C=C(C)C=C3)N2C1=NC=C2C.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BMS 345541

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	29.18	100
	DMSO	29.18	100

Preparing Stock Solutions for BMS 345541

The following data is based on the product molecular weight 291.78.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.43 mL	17.14 mL	34.27 mL
5 mM	0.69 mL	3.43 mL	6.85 mL
10 mM	0.34 mL	1.71 mL	3.43 mL
50 mM	0.07 mL	0.34 mL	0.69 mL

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References for BMS 345541

References are publications that support the biological activity of the product.

Burke BMS-345541 is a highly selective inhibitor of IκB kinase that binds at an allosteric site of the enzyme and blocks NF- κB-dependent transcription in mice. J.Biol.Chem. 2003 PMID: 12403772
De Silva Inhibition of choriodecidual cytokine production and inflammatory gene expression by selective IκB kinase (IKK) inhibitors. Br.J.Pharmacol. 2010 PMID: 20649582
Pattoli Collagen and aggrecan degradation is blocked in interleukin-1-treated cartilage explants by an inhibitor of IκB kinase through suppression of metalloproteinase expression. J.Pharmacol.Exp.Ther. 2005 PMID: 16009742